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首页> 外文期刊>Journal of International Medical Research >Effect of Esaprazole on Gastric Mucosal Potential Difference after Oral Administration of Aspirin (ASA)
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Effect of Esaprazole on Gastric Mucosal Potential Difference after Oral Administration of Aspirin (ASA)

机译：依沙普拉唑对口服阿司匹林（ASA）后胃黏膜电位差异的影响

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The potential protective properties of esaprazole on the gastric mucosa following administration of aspirin were evaluated by measurement of the potential difference across the gastric mucosa. Twelve patients with non-ulcer dyspepsia were admitted to the study and were divided into two groups of six patients each. In association with a randomized double-blind scheme the two groups of patients underwent two tests, with placebo and esaprazole 600 or 900 mg. After 30 min of basal recording of the potential difference, patients received either esaprazole or placebo i.v. and recording was continued for a further 30 min. Afterwards, 600 mg of unbuffered aspirin was instilled into the stomach through a nasogastric tube and the potential difference was measured for 60 min. Esaprazole 600 mg did not prevent the fall in the potential difference across the gastric mucosa caused by aspirin. A higher dose of esaprazole, however, did significantly (p≤0.05) reduce the fall. These results suggest that esaprazole exerts a dose-dependent cytoprotective effect on the gastric mucosa in man.
机译：通过测量整个胃粘膜上的电势差，评估了依阿司匹唑在服用阿司匹林后对胃粘膜的潜在保护性。十二名非溃疡性消化不良患者被纳入研究，分为两组，每组六名患者。结合随机双盲方案，两组患者分别接受了安慰剂和依沙普唑600或900 mg的两项测试。基础电位差记录30分钟后，患者接受依沙普唑或安慰剂静脉注射。并继续录制30分钟。然后，通过鼻胃管将600毫克未缓冲的阿司匹林滴入胃中，并测量60分钟的电位差。 600 mg依沙普拉唑不能防止阿司匹林引起的胃粘膜电位差下降。然而，较高剂量的依沙r唑确实能明显减少（p≤0.05）跌倒。这些结果表明，依沙哌唑对人的胃粘膜具有剂量依赖性的细胞保护作用。

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