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首页> 外文期刊>Journal of International Medical Research >Comparison of a Long-Acting Form of Propranolol and Conventional Propranolol in the Treatment of Hypertension in Elderly Patients
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Comparison of a Long-Acting Form of Propranolol and Conventional Propranolol in the Treatment of Hypertension in Elderly Patients

机译：长效普萘洛尔和常规普萘洛尔治疗老年高血压的比较

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摘要

Nineteen elderly hypertensive patients already being treated with a diuretic and, where necessary, another anti-hypertensive agent, were studied in a double-blind, randomized, crossover comparison of conventional propranolol, 40 mg three times daily, with a long-acting propranolol formulation, 160 mg once daily, as a second line agent. Patients were assessed before taking the morning's allocated medication. This was done as near as possible to 24 h after the last dose of once daily propranolol and as near as possible to 15 h after the last dose of three times daily conventional propranolol. Assessment was carried out at the time of randomization and after 4 weeks' treatment with both propranolol formulations. Heart rate and blood pressures were measured in the supine and standing positions and after exercise. Both propranolol formulations were effective as second line agents in these elderly patients and both were well tolerated. Patient compliance on both propranolol formulations was very good although the long-acting formulation may be of value in improving this still further.
机译：对已经接受利尿剂和必要时使用另一种降压药治疗的19位老年高血压患者进行了常规普萘洛尔的双盲，随机，交叉比较的研究，该常规普萘洛尔每天40毫克，长效普萘洛尔制剂，每天两次，一次160毫克。在服用早晨分配的药物之前对患者进行了评估。这是在每天一次普萘洛尔的最后一次剂量后的24小时内，以及在每天一次常规普萘洛尔的3次最后一次剂量后的15小时内，尽可能近地进行。在随机分配时和两种心得安制剂治疗4周后进行评估。在仰卧位和站立位以及运动后测量心率和血压。两种普萘洛尔制剂在这些老年患者中均有效作为二线药物，并且均具有良好的耐受性。尽管长效制剂可能对进一步改善患者的治疗价值，但两种普萘洛尔制剂的患者依从性都非常好。

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