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首页> 外文期刊>Journal of International Medical Research >The Effect of Food on the Absorption of Pivampicillin and a Comparison with the Absorption of Ampicillin Potassium
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The Effect of Food on the Absorption of Pivampicillin and a Comparison with the Absorption of Ampicillin Potassium

机译：食物对Pivampillillin吸收的影响以及与氨苄西林钾吸收的比较

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摘要

The effect of food on the absorption of pivampicillin hydrochloride and ampicillin potassium was compared in a single-dose, 3-way, cross-over study in fifteen healthy adult subjects. The antibiotics were given in their recommended doses in capsule form: 350 mg of pivampicillin and 500 mg of ampicillin. Ampicillin was administered in the fasting state while pivampicillin was administered both in the fasting state and during a standardized cooked breakfast. The presence of food caused a substantial decrease and delay in the absorption of pivampicillin. Pivampicillin administered during a meal, as recommended to minimize gastro-intestinal irritation, resulted in lower serum levels than those attained with ampicillin given without food. The average peak serum levels of pivampicillin taken during meals was 3.34 mcg/ml compared to 4.47 mcg/ml with ampicillin given in the fasting state. The total antibiotic coverage indicated by time-absorption curves was also considerably lower with pivampicillin than with ampicillin under conditions simulating those recommended during clinical use by the respective manufacturers.
机译：在十五名健康成人受试者的单剂量，三向，交叉研究中，比较了食物对盐酸吡伐比林和氨苄西林钾吸收的影响。抗生素以胶囊形式的推荐剂量给予：350 mg的匹维霉素和500 mg的氨苄青霉素。禁食状态下使用氨苄西林，而禁食状态下和标准熟食早餐中则同时使用匹维西林。食物的存在导致吡伐西林的吸收大量减少和延迟。为尽量减少对胃肠道的刺激，建议在进餐期间服用匹维西林，其血清水平要低于不食用氨苄西林时的血清水平。进餐期间匹维霉素的平均峰值血清水平为3.34 mcg / ml，而空腹状态下给予氨苄西林的平均峰值血清水平为4.47 mcg / ml。在模拟各自制造商在临床使用期间建议的使用条件下，用时间吸收曲线表示的总抗生素覆盖率在使用匹维霉素时比用氨苄西林要低得多。

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