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首页> 外文期刊>Journal of International Medical Research >Lipoperoxidation Induced by Hydrogen Peroxide in Human Erythrocyte Membranes
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Lipoperoxidation Induced by Hydrogen Peroxide in Human Erythrocyte Membranes

机译：过氧化氢在人红细胞膜中引起的脂质过氧化

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摘要

An in vitro model using healthy human erythrocyte suspensions was used to compare the antioxidant effect of standardized Ginkgo biloba extract (EGb 761) with those of water-soluble (ascorbic acid, glutathione and uric acid) and lipid-soluble (α-tocopherol and retinol acetate) antioxidants. Lipid peroxidation was induced by hydrogen peroxide in the absence (control) and presence of antioxidants at low (25 μg/ml) and high (250 μg/ml) concentrations. Malondialdehyde production was determined as the indicator of lipid peroxidation during the incubation period. The results suggest that all of the antioxidants, except ascorbic acid, have antioxidant potential in this system in a concentration-dependent manner. When the antioxidants were compared, EGb 761 was found to be more effective than water-soluble antioxidants, and as effective as lipid-soluble antioxidants. Among the lipid-soluble antioxidants there was no significant difference in potency between α-tocopherol and retinol acetate, but uric acid was the most potent of the water-soluble antioxidants. The antioxidant potency of EGb 761 appears to be comparable with that of the well-known antioxidants α-tocopherol and retinol acetate.
机译：使用健康人类红细胞悬液的体外模型比较了标准银杏叶提取物（EGb 761）与水溶性（抗坏血酸，谷胱甘肽和尿酸）和脂溶性（α-生育酚和视黄醇）的抗氧化作用醋酸盐）抗氧化剂。在不存在（对照）和存在低浓度（25μg/ ml）和高浓度（250μg/ ml）的抗氧化剂的情况下，过氧化氢可引起脂质过氧化。丙二醛的产生被确定为在孵育期间脂质过氧化的指标。结果表明，除抗坏血酸外，所有抗氧化剂在该系统中均具有浓度依赖性的抗氧化潜能。比较抗氧化剂时，发现EGB 761比水溶性抗氧化剂更有效，并且与脂溶性抗氧化剂一样有效。在脂溶性抗氧化剂中，α-生育酚和乙酸视黄醇之间的效力没有显着差异，但是尿酸是水溶性抗氧化剂中最有效的。 EGb 761的抗氧化剂功效似乎与众所周知的抗氧化剂α-生育酚和乙酸视黄醇相当。

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