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首页> 外文期刊>Journal of International Medical Research >Immunological Patterns during Regular Intensive Training in Athletes: Quantification and Evaluation of a Preventive Pharmacological Approach
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Immunological Patterns during Regular Intensive Training in Athletes: Quantification and Evaluation of a Preventive Pharmacological Approach

机译：运动员定期强化训练中的免疫模式：预防药理方法的量化和评估

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摘要

The effects of regular intensive exercise training on immune system homeostasis and the potential value of treatment with an immunostimulating agent were assessed in this randomized, double-blind, placebo-controlled, parallel-group study. A total of 60 athletes were studied over a 3-month period of regular intensive physical activity. After 1 and 3 months there were significant decreases in the immunoglobulin levels in the whole athlete population compared with baseline values. Specifically there were significant decreases in immunoglobulin M and immunoglobulin G (G1 and G2 subclasses). There was also a significant decrease in natural killer cells and a slight but significant increase in B and T lymphocytes. In the thymomodulin-treated group, unlike the placebo group, there was no significant decrease in the immunoglobulin G2 subclass and there was a significant increase in the T-helper cell subpopulation. The clinical relevance of these immunological findings should be evaluated in larger clinical and epidemiological studies.
机译：在这项随机，双盲，安慰剂对照，平行组研究中，评估了定期强化运动对免疫系统稳态的影响以及使用免疫刺激剂治疗的潜在价值。在为期3个月的定期密集体育锻炼期间，总共对60名运动员进行了研究。 1个月和3个月后，与基线值相比，整个运动员群体中的免疫球蛋白水平显着下降。具体而言，免疫球蛋白M和免疫球蛋白G（G1和G2亚类）显着减少。自然杀伤细胞也显着减少，B和T淋巴细胞略有但显着增加。在胸腺调节素治疗组中，与安慰剂组不同，免疫球蛋白G2亚类没有显着减少，T辅助细胞亚群也有显着增加。这些免疫学发现的临床相关性应在较大的临床和流行病学研究中进行评估。

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