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首页> 外文期刊>Journal of International Medical Research >Double-Blind Evaluation of Domperidone in Acute Vomiting and Dyspeptic Disorders
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Double-Blind Evaluation of Domperidone in Acute Vomiting and Dyspeptic Disorders

机译：多潘立酮在急性呕吐和消化不良中的双盲评估

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摘要

The anti-emetic effects of domperidone were evaluated under double-blind conditions in twenty-four patients with acute vomiting randomly assigned to treatment either with 10 mg i.m. domperidone (six females, five males) or with placebo (seven females, six males). The therapeutic results were better with domperidone and the differences from placebo were statistically significant (p < 0.02). In a second randomized, crossover, double-blind trial, domperidone (10 mg t.i.d.) evaluated according to a nine-symptom rating scale, in eighteen dyspeptic patients, proved significantly more effective than placebo. The duration of treatment was 6 weeks and the drugs were crossed-over after 3 weeks. The difference between the two groups was most marked during the second phase of the trial. No side-effects were reported.
机译：在双盲条件下评估了随机分配接受10 mg i.m.治疗的24例急性呕吐患者的多潘立酮的止吐作用。多潘立酮（六位女性，五位男性）或安慰剂（七位女性，六位男性）。多潘立酮治疗效果更好，与安慰剂的差异有统计学意义（p <0.02）。在第二项随机，交叉，双盲试验中，根据18例消化不良患者的9症状评分量表对多潘立酮（10 mg t.i.d.）进行了评估，事实证明它比安慰剂有效得多。治疗时间为6周，药物在3周后交叉使用。两组之间的差异在试验的第二阶段最为明显。没有副作用的报道。

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