Effect of a Gel Formulation of Sucralfate on Gastric Microcirculation

M Guslandi; M Sorghi; A Foppa; PC Braga; A Tittobello

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Effect of a Gel Formulation of Sucralfate on Gastric Microcirculation

机译：硫糖铝凝胶制剂对胃微循环的影响

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Dyspeptic patients (n = 12) with endoscopic signs of chronic gastritis were treated orally for 28 days with a new gel formulation of sucralfate at a dose of 1 g twice daily. Before and after treatment, gastric blood flow was assessed during endoscopy by means of laser Doppler flowmetry. The sucralfate gel promoted a significant increase (P < 0.001) in blood perfusion in all patients, restoring normal levels of gastric microcirculation. The results are consistent with observations in animals, suggesting that the mechanisms responsible for the gastroprotective and therapeutic properties of sucralfate include enhancement of mucosal blood flow.

机译：患有内镜症状的慢性胃炎消化不良的患者（n = 12）接受口服硫糖铝新凝胶制剂口服治疗28天，每天两次，每次1 g。治疗前后，在胃镜检查期间通过激光多普勒血流仪评估胃血流量。硫糖铝凝胶促进所有患者血液灌注的显着增加（P <0.001），恢复了胃微循环的正常水平。结果与在动物中的观察结果一致，表明负责硫糖铝的胃保护和治疗特性的机制包括粘膜血流的增强。

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《Journal of International Medical Research》 |1993年第1期|共4页
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M Guslandi; M Sorghi; A Foppa; PC Braga; A Tittobello;
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Effect of a Gel Formulation of Sucralfate on Gastric Microcirculation

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