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首页> 外文期刊>Journal of International Medical Research >Analysis of the Relationship between Sex and Chromosomal Aberrations in Colorectal Cancer by Comparative Genomic Hybridization
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Analysis of the Relationship between Sex and Chromosomal Aberrations in Colorectal Cancer by Comparative Genomic Hybridization

机译：比较基因组杂交技术分析大肠癌性别与染色体畸变的关系

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Colorectal cancer is thought to be more common in men than in women. The chromosomal locations of DNA gains and losses in surgical specimens of colorectal tumours were detected by comparative genomic hybridization and were compared by gender. Five chromosomal regions, 7p, 8p, 8q, Xp and Xq, contained multiple gains that were significantly more common in males than in females, and within these regions, the differences were significant for Xp21, Xp11.3, Xp11.4 and Xq26. Regions 1p, 3q, 11q, 12p, 12q and 15q contained multiple sites of gain that were significantly more common in females than in males. Tumours from male and female patients showed significantly more losses at 11p and 15q, and at 4q and Xq, respectively. The fact that gains in X-chromosomal regions were detected with a significantly higher frequency in tumours from male patients suggests that the difference between the genders might be explained by X-chromosomal inactivation.
机译：人们认为大肠癌在男性中比在女性中更为普遍。通过比较基因组杂交检测大肠肿瘤手术标本中DNA得失的染色体位置，并按性别进行比较。五个染色体区域7p，8p，8q，Xp和Xq包含多个增益，男性明显高于女性，并且在这些区域内，Xp21，Xp11.3，Xp11.4和Xq26的差异显着。 1p，3q，11q，12p，12q和15q区域包含多个增益位点，女性明显多于男性。男性和女性患者的肿瘤分别在11p和15q，4q和Xq处显示出明显更多的损失。在男性患者的肿瘤中检测到X染色体区域的增益明显更高的事实表明，性别之间的差异可能由X染色体失活所解释。

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