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首页> 外文期刊>Journal of International Medical Research >A Multicentre General Practice Study to Compare Psoradrate 0.1% and Dithrocream 0.1% in the Treatment of Chronic Psoriasis
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A Multicentre General Practice Study to Compare Psoradrate 0.1% and Dithrocream 0.1% in the Treatment of Chronic Psoriasis

机译：多中心综合实践研究比较0.1％的甲磺酸和0.1％的双硫脂治疗慢性牛皮癣

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摘要

A multicentre general practice study was undertaken to compare the efficacy of two proprietary dithranol preparations, Psoradrate 0.1% and Dithrocream 0.1%, in the treatment of chronic psoriasis, using a single-blind, within-patient trial design. A total of forty-nine patients entered the study and treatment lasted for 6 weeks. Psoradrate 0.1% produced a greater mean per cent clinical improvement in psoriasis than Dithrocream 0.1% at each stage of the trial, and this difference was statistically significant (p = 0.025) at 4 weeks. The evidence also suggested that Psoradrate 0.1% resulted in greater reductions in psoriatic scaling. Most patients found that the Psoradrate 0.1% was more effective and a significant majority (p=0.01) thought that it worked faster than Dithrocream 0.1%. Although the increased effectiveness of the Psoradrate 0.1% was associated with a higher incidence of stinging/burning of the skin, this was not reflected in the patients' overall opinions of the treatments. Twenty-three patients preferred Psoradrate as against seventeen who preferred Dithrocream.
机译：进行了一项多中心的一般实践研究，以单盲患者内试验设计比较两种专有的二乙醇胺制剂（Psoradrate 0.1％和Dithrocream 0.1％）在治疗慢性牛皮癣中的功效。共有49位患者进入研究，治疗持续了6周。在试验的每个阶段，0.1％的Psoradrate产生的银屑病临床平均改善率均高于Dithrocream 0.1％的平均改善率，并且在4周时，该差异具有统计学意义（p = 0.025）。证据还表明，Psoradrate 0.1％导致银屑病结垢的更大程度降低。大多数患者发现0.1％的Psoradrate更有效，并且大多数患者（p = 0.01）认为它的作用比0.1％的Dithrocream更快。尽管0.1％的Psoradrate的有效性提高与皮肤刺痛/灼伤的发生率更高相关，但这并未反映在患者对治疗的总体看法中。 23名患者首选Psoradrate，而17名患者首选Dithrocream。

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