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首页> 外文期刊>Journal of International Medical Research >Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma
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Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma

机译：Capn4 mRNA水平与透明细胞肾细胞癌的肿瘤进展和临床结果相关

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Objective To investigate the mRNA and protein levels of calpain small subunit-1 (Capn4) in human clear cell renal cell carcinoma (ccRCC), to analyse the relationship between Capn4 mRNA level and pathological stage of ccRCC, and to examine the potential of Capn4 as a prognostic factor in ccRCC. Methods mRNA and protein levels of Capn4 were measured in pairs of tumour tissues and matched adjacent nontumour tissue obtained from patients with ccRCC by quantitative reverse transcription–polymerase chain reaction (qRT–PCR) and Western blotting, respectively. Associations of the mRNA level of Capn4 with pathological tumour stage and the overall survival of ccRCC patients were also analysed. Results Capn4 mRNA and protein level were significantly higher in ccRCC tumour tissues compared with adjacent nontumour tissues as assessed by qRT-PCR and Western blotting, respectively. Higher Capn4 mRNA levels were observed in patients with more advanced pathological stage of ccRCC and were also associated with decreased overall survival of patients with ccRCC. Conclusions The findings from this study indicate that Capn4 has the potential to be an independent prognostic indicator for ccRCC.
机译：目的探讨人透明细胞肾细胞癌（ccRCC）中钙蛋​​白酶小亚基1（Capn4）的mRNA和蛋白水平，分析Capn4 mRNA水平与ccRCC病理分期的相关性，并探讨Capn4作为肝癌的潜力。 ccRCC的预后因素。方法分别通过定量逆转录-聚合酶链反应（qRT-PCR）和Western印迹法从ccRCC患者中检测成对的肿瘤组织和匹配的相邻非肿瘤组织中Capn4的mRNA和蛋白水平。还分析了Capn4的mRNA水平与病理性肿瘤分期和ccRCC患者总体生存率的关系。结果通过qRT-PCR和Western blotting评估，ccRCC肿瘤组织中Capn4 mRNA和蛋白水平显着高于邻近的非肿瘤组织。在ccRCC病理更晚期的患者中观察到较高的Capn4 mRNA水平，也与ccRCC患者的整体生存期降低有关。结论本研究的结果表明Capn4有可能成为ccRCC的独立预后指标。

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