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首页> 外文期刊>Journal of Lasers in Medical Sciences >Combination of Q-Switched Nd:YAG and Fractional Erbium:YAG Lasers in Treatment of Melasma: A Randomized Controlled Clinical Trial
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Combination of Q-Switched Nd:YAG and Fractional Erbium:YAG Lasers in Treatment of Melasma: A Randomized Controlled Clinical Trial

机译：调Q Nd：YAG和分数Er：YAG激光联合治疗黄褐斑的随机对照临床试验

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Introduction: Ablative and nonablative lasers have been used to treat melasma. We aimed to assess and compare the combining Q-switched Nd:YAG laser (QSNYL) and fractional erbium:YAG laser (FEYL) with QSNYL alone in treatment of melasma. Methods: This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Women with melasma and without a history of keloid formation, hypersensitivity to hydroquinone, or pigmentary changes due to laser therapy were randomly allocated to receive four sessions of either QSNYL-FEYL combination or QSNYL alone. All patients received topical treatment with Kligman’s formula. Before laser therapy and 4 weeks after the last treatment session, patients’ skin was assessed for changes in skin color, melanin content, and erythema intensity of melasma lesions quantitatively. Results: Finally, 21 patients in QSNYL-FEYL and 20 in QSNYL group (mean age, 38.57 [5.60] and 42.60 [8.44] years, respectively) completed study. The skin color had become lighter in both groups (mean [SD] percentage change of 56.95 [40.29] and 29.25 [13.20] in QSNYL-FEYL and QSNYL groups, respectively) with significantly better results in QSNYL-FEYL group ( P = 0.006). Percentage of decrease of melanin content was significantly higher in QSNYL-FEYL group (22.01 [10.67] vs. 7.69 [4.75]; P & 0.001). After adjustment for baseline values, the post treatment intensity of erythema was significantly lower in QSNYL-FEYL group ( P & 0.001). The patients reported no adverse events. Conclusion: QSNYL-FEYL was significantly more effective in decreasing melanin content of lesions than QSNYL and led to a lighter skin. ?
机译：简介：烧蚀和非烧蚀激光已用于治疗黄褐斑。我们旨在评估和比较Q开关Nd：YAG激光（QSNYL）和分数and：YAG激光（FEYL）与单独的QSNYL组合治疗黄褐斑的效果。方法：该随机对照临床试验于2013-2014年在我们的研究中心进行。没有黄褐斑，没有瘢痕loid形成，对氢醌过敏或激光治疗引起的色素变化的女性被随机分配接受四个疗程的QSNYL-FEYL组合或QSNYL治疗。所有患者均接受了克利格曼配方的局部治疗。在激光治疗之前和最后一次治疗之后的4周，定量评估患者皮肤的肤色，黑色素含量和黄褐斑病变的红斑强度。结果：最后，完成了QSNYL-FEYL的21例患者和QSNYL组的20例（平均年龄分别为38.57 [5.60]和42.60 [8.44]岁）。两组的肤色都变浅（QSNYL-FEYL和QSNYL组的平均[SD]百分比变化分别为56.95 [40.29]和29.25 [13.20]），而QSNYL-FEYL组的结果明显更好（P = 0.006） 。在QSNYL-FEYL组中，黑色素含量降低的百分比显着更高（22.01 [10.67]对7.69 [4.75]; P ＜0.001）。调整基线值后，QSNYL-FEYL组的红斑的治疗后强度明显降低（P <0.001）。患者未报告不良事件。结论：QSNYL-FEYL在减少病变中黑色素含量方面比QSNYL显着更有效，并且可以使皮肤更白。 ？

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