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首页> 外文期刊>Journal of International Medical Research >Lipoproteins in the Elderly
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Lipoproteins in the Elderly

机译：老年人脂蛋白

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Changes in lipid metabolism with age result in lower total serum cholesterol and low-density lipoprotein concentrations. There is no evidence that longevity and lipid profiles are influenced by genetic make-up. It is difficult to establish an optimum total serum cholesterol in the elderly but values established in younger subjects give a guide. High-density lipoprotein may be even more protective in the elderly and could turn out to be a better predictor of coronary disease. Screening for the treatment of hypercholesterolemia should be carried out in the elderly. Although death is an inevitable fact, intervention in, for example, recently retired, apparently disease-free subjects is important. The first approach should be the introduction of changes in life style (increased exercise, stopping smoking, improved diet). Drugs may also be introduced if these interventions fail. Although drug therapy in the elderly may pose immediate problems due to poor renal and hepatic function, the adverse effects of long-term use have less relevance in the elderly.
机译：脂质代谢随着年龄的变化而导致血清总胆固醇降低和低密度脂蛋白浓度降低。没有证据表明寿命和脂质分布受遗传组成的影响。很难在老年人中确定最佳的总血清胆固醇，但是在年轻受试者中确定的值可以提供指导。高密度脂蛋白在老年人中可能更具保护作用，并可能成为冠状动脉疾病的更好预测指标。高胆固醇血症治疗的筛查应在老年人中进行。尽管死亡是不可避免的事实，但是对例如最近退休，显然没有疾病的受试者进行干预很重要。第一种方法应该是改变生活方式（增加运动，戒烟，改善饮食习惯）。如果这些干预措施失败，也可能会引入毒品。尽管由于肾和肝功能不佳，老年人的药物治疗可能会带来直接的问题，但长期使用的不良反应与老年人的相关性较小。

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