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首页> 外文期刊>Journal of Immune Based Therapies Vaccines >Cellular metabolism as a basis for immune privilege
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Cellular metabolism as a basis for immune privilege

机译：细胞代谢是免疫特权的基础

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We hypothesize that the energy strategy of a cell is a key factor for determining how, or if, the immune system interacts with that cell. Cells have a limited number of metabolic states, in part, depending on the type of fuels the cell consumes. Cellular fuels include glucose (carbohydrates), lipids (fats), and proteins. We propose that the cell's ability to switch to, and efficiently use, fat for fuel confers immune privilege. Additionally, because uncoupling proteins are involved in the fat burning process and reportedly in protection from free radicals, we hypothesize that uncoupling proteins play an important role in immune privilege. Thus, changes in metabolism (caused by oxidative stresses, fuel availability, age, hormones, radiation, or drugs) will dictate and initiate changes in immune recognition and in the nature of the immune response. This has profound implications for controlling the symptoms of autoimmune diseases, for preventing graft rejection, and for targeting tumor cells for destruction.
机译：我们假设细胞的能量策略是确定免疫系统如何或是否与该细胞相互作用的关键因素。细胞的代谢状态有限，部分取决于细胞消耗的燃料类型。细胞燃料包括葡萄糖（碳水化合物），脂质（脂肪）和蛋白质。我们建议细胞转换为脂肪并有效使用脂肪的能力赋予免疫特权。此外，由于解偶联蛋白参与了脂肪燃烧过程，据报道其参与了自由基保护作用，因此我们推测解偶联蛋白在免疫特权中起着重要作用。因此，新陈代谢的变化（由氧化应激，燃料供应，年龄，激素，辐射或药物引起）将决定并引发免疫识别和免疫反应性质的变化。这对于控制自身免疫性疾病的症状，防止移植物排斥以及靶向破坏肿瘤细胞具有深远的意义。

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