...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Lasers in Medical Sciences >Photothrombosis of Corneal Neovascularization by Photodynamic Therapy Utilizing Verteporfin and Diode Laser
【24h】

Photothrombosis of Corneal Neovascularization by Photodynamic Therapy Utilizing Verteporfin and Diode Laser

机译：Verteporfin和二极管激光光动力疗法治疗角膜新生血管的光血栓形成

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: The aim of the present study was to evaluate the effect of photodynamic therapy in the treatment of experimental corneal neovascularization (NV) with benzoporphyrin derivative (BPD). Methods: One group was considered as control (n=6 eyes) then, corneal NV was induced in 30 New Zealand male rabbits (n=60 eyes) by placing 7.0 silk sutures at midstromal depth approximately1mm from the limbus. Fifteen rabbits with corneal NV were left without any treatment, and 15 rabbits were subjected to photodynamic therapy (PDT) by intravenous injection with Verteporfin at a dose of 1.5 mg /Kg. Diode laser (660 nm) was applied after 15minutes for 5 minutes with a power of 50 mW/cm2. All rabbits were successively followed up by slit lamp examination for periods of 1 day, 1, 2, 3 and 4 weeks. Three rabbits were selected and sacrificed weekly (n=6 eyes each) and the corneas were isolated for histopathological examination. Results: The results of slit lamp examination indicated the gradual regression of the cornea neovascularization 4 weeks of PDT. Furthermore, regression of corneal neovascularization was documented clinically by decrease number and length of blood vessels and by histopathological examination. Conclusion: PDT with Verteporfin can provide efficacious treatment of corneal neovascularization.
机译：简介：本研究的目的是评估光动力学疗法对苯并卟啉衍生物（BPD）治疗实验性角膜新生血管（NV）的效果。方法：以一组为对照组（n = 6只眼），然后在离角膜缘约1mm的中基质深度放置7.0丝线，在30只新西兰雄性兔子（n = 60只眼）中诱导角膜NV。剩下的15只具有角膜NV的兔子未经任何治疗，并且通过静脉内注射1.5mg / Kg的Verteporfin对15只兔子进行光动力疗法（PDT）。 15分钟后以50 mW / cm2的功率施加二极管激光器（660 nm），持续5分钟。连续对所有兔子进行裂隙灯检查，持续1天，1、2、3和4周。选择三只兔子，每周处死（每只n ＝ 6只眼睛），并分离角膜用于组织病理学检查。结果：裂隙灯检查的结果表明PDT 4周后角膜新生血管逐渐消退。此外，临床上通过减少血管的数量和长度以及通过组织病理学检查证明了角膜新生血管的消退。结论：PDT与维替泊芬可以有效治疗角膜新生血管。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号