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首页> 外文期刊>Journal of International Medical Research >The Effectiveness of a Weak Opioid Medication versus a Cyclo-Oxygenase-2 (COX-2) Selective Non-Steroidal Anti-Inflammatory Drug in Treating Flare-Up of Chronic Low-Back Pain: Results from Two Randomized, Double-Blind, 6-Week Studies
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The Effectiveness of a Weak Opioid Medication versus a Cyclo-Oxygenase-2 (COX-2) Selective Non-Steroidal Anti-Inflammatory Drug in Treating Flare-Up of Chronic Low-Back Pain: Results from Two Randomized, Double-Blind, 6-Week Studies

机译：阿片类药物治疗与环氧化酶2（COX-2）选择性非甾体类抗炎药相比，对治疗慢性下腰痛发作的有效性：两种随机，双盲，6-周学

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摘要

Two 6-week studies compared the analgesic efficacy, tolerability and safety of a non-steroidal anti-inflammatory drug (celecoxib 200 mg twice a day [bid]) and an opioid (tramadol HCl 50 mg four times a day [qid]) in subjects with chronic low-back pain (CLBP). Successful responders (primary endpoint) were defined as subjects completing 6 weeks of treatment and having ≥ 30% improvement on the Numerical Rating Scale for pain. A total of 796 and 802 subjects were randomized to treatment in study 1 and study 2, respectively. A significantly greater percentage of celecoxib-treated subjects were successful responders compared with tramadol HCl-treated subjects (study 1: 63.2% versus 49.9%, respectively; study 2: 64.1% versus 55.1%, respectively). Fewer adverse events (AEs) and serious AEs were reported in the celecoxib-treated group. Overall, celecoxib 200 mg bid was more effective than tramadol HCl 50 mg qid in the treatment of CLBP, with fewer AEs reported.
机译：两项为期6周的研究比较了非甾体类抗炎药（塞来昔布200毫克，一天两次，每天两次[出价]）和阿片类药物（曲马多HCl 50毫克，一天四次，每天[qid]）的镇痛效果，耐受性和安全性。患有慢性腰背痛（CLBP）的受试者。成功的反应者（主要终点）定义为完成治疗6周且疼痛数字评分量表改善≥30％的受试者。总共796名受试者和802名受试者分别被随机分配至研究1和研究2。与盐酸曲马多治疗的受试者相比，塞来昔布治疗的受试者是成功的应答者（研究1：分别为63.2％和49.9％;研究2：分别为64.1％和55.1％）。塞来昔布治疗组的不良事件（AE）和严重不良事件较少。总体而言，塞来昔布200 mg bid在治疗CLBP方面比盐酸曲马多50 mg qid更有效，报道的AE较少。

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