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首页> 外文期刊>Journal of International Medical Research >RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis
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RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis

机译：在异位和异位子宫内膜中的RhoA / ROCK / ARHGAP26信号传导参与子宫腺肌病的临床特征

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Objective This study aimed to investigate RhoA, RhoA-associated coiled-coil containing protein kinase (ROCK) 1, ROCK2, and Rho GTPase-activating protein 26 (ARHGAP26) expression in the eutopic endometrium (EU) and ectopic endometrium (EC), and examine their relationships with the clinical characteristics of adenomyosis. Methods Twenty patients with adenomyosis who underwent laparoscopy were recruited. Protein and mRNA expression of RhoA, ROCK1, ROCK2, and ARHGAP26 in EU and EC of patients with adenomyosis and in control endometrium without adenomyosis (CE) was detected. Results ROCK1, ROCK2, and RhoA mRNA expression in EU was significantly higher than that in CE, and was highest in EC. ARHGAP26 mRNA expression in EC and EU was significantly lower than that in CE. ROCK1, ROCK2, and RhoA protein expression in EC and EU was significantly higher than that in CE. ARHGAP26 protein expression in EC and EU was significantly lower than that in CE. ROCK1, ROCK2, and RhoA gene and protein expression was positively associated and ARHGAP26 was negatively associated with the severity of menorrhagia and menstrual capacity in adenomyosis. Conclusions RhoA, ROCK1, and ROCK2 expression is upregulated, and ARHGAP26 expression is downregulated in adenomyosis. The RhoA/ROCK-mediated signaling pathway is associated with dysmenorrhea and menstrual capacity in adenomyosis.
机译：目的本研究旨在探讨RhoA，与RhoA相关的卷曲螺旋蛋白激酶（ROCK）1，ROCK2和Rho GTPase激活蛋白26（ARHGAP26）在异位内膜（EU）和异位内膜（EC）中的表达，以及检查他们与子宫腺肌症临床特征的关系。方法招募20例行腹腔镜检查的子宫腺肌病患者。检测了子宫腺肌病患者和正常子宫内膜无子宫肌病（CE）患者的EU和EC中RhoA，ROCK1，ROCK2和ARHGAP26的蛋白质和mRNA表达。结果EU中的ROCK1，ROCK2和RhoA mRNA表达显着高于CE，在EC中最高。 EC和EU中ARHGAP26 mRNA的表达显着低于CE。 EC和EU中的ROCK1，ROCK2和RhoA蛋白表达显着高于CE。 EC和EU中的ARHGAP26蛋白表达明显低于CE。 ROCK1，ROCK2和RhoA基因和蛋白质表达与月经过多的严重程度和子宫腺肌病的月经能力呈负相关，而ARHGAP26与月经的严重程度呈负相关。结论子宫腺肌病中RhoA，ROCK1和ROCK2的表达上调，而ARHGAP26的表达下调。 RhoA / ROCK介导的信号通路与痛经和子宫腺肌病的月经能力有关。

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