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首页> 外文期刊>Journal of investigational allergology & clinical immunology: official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologie >Bronchial Hyperresponsiveness and Airway Inflammation in Patients With Seasonal Allergic Rhinitis
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Bronchial Hyperresponsiveness and Airway Inflammation in Patients With Seasonal Allergic Rhinitis

机译：季节性变应性鼻炎患者的支气管高反应性和气道炎症

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Background: Allergic rhinitis is a chronic inflammatory disease induced by an immunoglobulin (Ig) E?mediated reaction after exposure to an allergen. Many patients with allergic rhinitis and no clinical evidence of asthma show a heightened response to histamine.Objectives: The aims of the study were to measure changes in markers of airway inflammation in patients with seasonal allergic rhinitisand estimate changes in bronchial reactivity before and during the pollen season.Methods: The study sample comprised 22 patients sensitized to grass pollen and 10 healthy volunteers. Based on the results of the bronchial provocation test (BPT) during the pollen season, we divided patients into those with and without bronchial hyperresponsiveness (BHR). We determined changes in nitrite and pH in exhaled breath concentrate (EBC), fraction of exhaled nitric oxide (FENO), blood eosinophil count, and BPT results before and during the pollen season.Results: In allergic rhinitis patients with BHR, we observed an increase in EBC nitrite(5.44 [2.33] vs 8.57 [3.35] nmol/mL, P=.02) and FENO (20.90 [13.68] vs. 43.40 [31.60] ppb, P=.02) and a decrease in EBC pH (7.07 [0.33] vs. 6.74 [0.28], P=.01) during the pollen season. In allergic rhinitis patients with BHR, the increase in BHR was negatively correlated with increased FENO and EBC nitrite and positively correlated with a decrease in EBC pH during the pollen season.Conclusions: Our results revealed a relationship between increased BHR in patients with seasonal allergic rhinitis and changes in airway inflammation markers. EBC pH, EBC nitrite concentration, and FENO could act as prognostic markers for identifying patients at risk of developing asthma.Key words: Allergic rhinitis. Bronchial hyperresponsiveness. Allergic inflammation. Exhaled breath condensate. Exhaled nitric oxide.
机译：背景：过敏性鼻炎是一种慢性炎性疾病，是由暴露于过敏原后的免疫球蛋白（Ig）E介导的反应诱导的。许多过敏性鼻炎患者没有哮喘的临床证据显示对组胺的反应增强。目的：本研究的目的是测量季节性过敏性鼻炎患者气道炎症标志物的变化，并评估花粉前后的支气管反应性变化。方法：研究样本包括22名对花粉敏感的患者和10名健康志愿者。根据花粉季节中支气管激发试验（BPT）的结果，我们将患者分为具有和不具有支气管高反应性（BHR）的患者。在花粉季节之前和期间，我们确定了呼出气浓缩物（EBC），呼出气一氧化氮（FENO）的分数，呼出气一氧化氮（FENO）的分数，血液嗜酸性粒细胞计数和BPT结果的变化。结果：在BHR过敏性鼻炎患者中，我们观察到亚硝酸盐EBC增加（5.44 [2.33] vs 8.57 [3.35] nmol / mL，P = .02）和FENO（20.90 [13.68] vs. 43.40 [31.60] ppb，P = .02），EBC pH降低（在花粉季节中，分别为7.07 [0.33]和6.74 [0.28]，P = .01）。在花粉季节中，变态反应性鼻炎患者的BHR升高与FENO和EBC亚硝酸盐的增加呈负相关，而与花粉季节EBC pH的降低呈正相关。和呼吸道炎症标志物的变化EBC pH，EBC亚硝酸盐浓度和FENO可以作为识别患哮喘风险的患者的预后标志物。关键词：过敏性鼻炎。支气管高反应性。过敏性炎症。呼出气凝结。呼出一氧化氮。

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