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首页> 外文期刊>Journal of investigational allergology & clinical immunology: official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologie >Are Basophil Activation and Sulphidoleukotriene Determination Useful Tests for Monitoring Patients With Peach Allergy Receiving Sublingual Immunotherapy With a Pru p 3-Enriched Peach Extract?
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Are Basophil Activation and Sulphidoleukotriene Determination Useful Tests for Monitoring Patients With Peach Allergy Receiving Sublingual Immunotherapy With a Pru p 3-Enriched Peach Extract?

机译：嗜碱性粒细胞活化和磺酰三烯三烯测定是否可用于监测患有桃过敏的患者接受富含Pru p 3的桃提取物进行舌下免疫治疗？

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Introduction: Treatment of food allergy essentially consists of food avoidance, but immunotherapy with food is emerging as a new therapeutic option.Objective: To evaluate clinical improvement and immunological changes in patients with peach allergy following sublingual immunotherapy (SLIT) with a Pru p 3 quantified peach extract.Methods: A randomized, double-blind, placebo-controlled clinical trial with peach SLIT was conducted. We assessed clinical efficacy after 6 months of treatment by means of double-blind, placebo-controlled oral challenges with peach and also evaluated immunological changes (basophil activation test [BAT] and determination of sulphidoleukotriene production) following stimulation with peach peel and pulp, rPru p 3, rMal d 1, and rMal d 4 stimulation. We also measured specific IgE and IgG4 to Pru p 3.Results: After 6 months of SLIT (T6), the active group showed a 3-fold improvement in tolerance to Pru p 3 and a significant increase in IgE to rPru p 3 and in sLT production following stimulation with peach peel and rPru p 3. There was also a significant increase in BAT results after stimulation with rPru p 3 at 1 month of SLIT (T1). Statistically significant between-group differences were only observed for BAT with peach peel and pulp at T1 and T6 and for BAT with rPru p 3 at T6. No changes were observed in BAT with rMal d 1 or rMal d 4 or in IgG4 levels to nPru p 3.Conclusions: SLIT with a Pru p 3 quantified peach extract is clinically effective and leads to an increase in basophil activation and sulphidoleukotriene production following stimulation with rPru p 3 and peach peel in the first months of treatment.Key words: Basophil. CAST. Food immunotherapy. Lipid transfer protein. Sublingual immunotherapy. Peach immunotherapy. LTP.
机译：简介：对食物过敏的治疗基本上包括避免食物，但食物免疫治疗正在成为一种新的治疗选择。目的：通过定量Pru p 3评估舌下免疫疗法（SLIT）后桃过敏患者的临床改善和免疫学变化。方法：采用桃SLIT进行了一项随机，双盲，安慰剂对照的临床试验。我们通过桃子皮和果肉刺激后，通过双盲，安慰剂对照的口服桃子双盲，口服安慰剂对照口服药物治疗评估了临床疗效，并评估了免疫学变化（嗜碱性粒细胞活化试验[BAT]和硫代白三烯产量的测定） p 3，rMal d 1和rMal d 4刺激。我们还测量了对Pru p 3的特异性IgE和IgG4。结果：在SLIT（T6）6个月后，活性组对Pru p 3的耐受性提高了3倍，对rPru p 3和iPe的IgE显着提高。桃皮和rPru p 3刺激后，sLT的产生。在SLIT（T1）1个月后，用rPru p 3刺激后，BAT结果也显着增加。组间差异仅在T1和T6的桃皮和果肉的BAT和T6的rPru p 3的BAT上具有统计学意义。在rMal d 1或rMal d 4或IgG4水平至nPru p 3的BAT中未观察到任何变化。结论：SLIT和Pru p 3定量桃提取物在临床上是有效的，并导致刺激后嗜碱性粒细胞活化和亚硫白三烯产量增加在治疗的头几个月中使用rPru p 3和桃皮。关键词：嗜碱性粒细胞。投。食品免疫疗法。脂质转移蛋白。舌下免疫治疗。桃子免疫疗法。 LTP。

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