The Beneficial Effect of Melatonin on Chronic Cyclosporin a Nephrotoxicity in Rats

M E?refo?lu; M Kuru?; E ?ahna

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The Beneficial Effect of Melatonin on Chronic Cyclosporin a Nephrotoxicity in Rats

机译：褪黑素对大鼠慢性环孢菌素的肾毒性的有益作用

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Cyclosporin A (CsA)-induced nephrotoxicity may be the consequence of oxidative stress. Anti-oxidant agents could be useful in reducing CsA toxicity. In this light microscopy study, tubular dilatation, atrophy, vacuolization and tubulointerstitial fibrosis were observed in rats given CsA, whereas in rats given CsA plus melatonin, no histological changes occurred. It is concluded that melatonin could be useful for reducing the nephrotoxic effects of CsA.

机译：环孢菌素A（CsA）诱导的肾毒性可能是氧化应激的结果。抗氧化剂可用于降低CsA毒性。在该光学显微镜研究中，在给予CsA的大鼠中观察到了肾小管扩张，萎缩，空泡化和肾小管间质纤维化，而给予CsA和褪黑激素的大鼠未发生组织学改变。结论是褪黑激素可用于降低CsA的肾毒性作用。

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《Journal of International Medical Research》 |2003年第1期|共3页
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M E?refo?lu; M Kuru?; E ?ahna;
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The Beneficial Effect of Melatonin on Chronic Cyclosporin a Nephrotoxicity in Rats

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