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首页> 外文期刊>Journal of International Medical Research >Induction of Myocarditis Lesions in Lewis Rats by Formalin-Killed Cells of Group a Streptococcus
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Induction of Myocarditis Lesions in Lewis Rats by Formalin-Killed Cells of Group a Streptococcus

机译：A组链球菌福尔马林杀伤细胞诱导Lewis大鼠心肌炎病变

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The feasibility of inducing rheumatic myocarditis lesions in Lewis rats by immunization with formalin-killed group A Streptococcus was evaluated. The rats were divided into three groups. Group A was immunized by injecting formalin-killed group A Streptococcus suspended in complete Freund's adjuvant (CFA) into the hind-foot pads and repeat immunization was given 1 week later by subcutaneous injection into the belly. The rats were then sacrificed 3 weeks after the initial immunization. In group B, the rats received the same initial immunization as group A, but the repeat immunization was carried out at 1, 2 and 3 weeks after the initial immunization and the rats were sacrificed 6 weeks after the initial immunization. Group C was a control group with the rats injected with saline/CFA and sacrificed on the same schedule as group A. Heart pathology sections showed that myocarditis lesions, focal inflammatory cell infiltration in interstitial near small vessels and valvulitis were induced in Lewis rats following immunization with formalin-killed group A Streptococcus.
机译：评估了用福尔马林杀死的A组链球菌免疫接种在Lewis大鼠中诱导风湿性心肌炎病变的可行性。将大鼠分为三组。通过将福尔马林杀死的A组链球菌悬浮在完全弗氏佐剂（CFA）中注射到后足垫中，从而对A组进行免疫，并于1周后通过皮下注射到腹部中进行重复免疫。然后在初次免疫3周后处死大鼠。在B组中，大鼠接受与A组相同的初次免疫，但是在初次免疫后1、2和3周进行重复免疫，并且在初次免疫后6周处死大鼠。 C组为对照组，大鼠注射生理盐水/ CFA并按与A组相同的时间表处死。心脏病理切片显示，免疫后Lewis大鼠诱发心肌炎病变，小血管间质中的局灶性炎性细胞浸润和瓣膜炎用福尔马林杀死的A组链球菌。

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