Impaired aortic distensibility in hypothyroid patients with negative coronary angiograms: Simultaneous evaluation with 128-slice multiple row detector computed tomography

Abdurrahim Dusak; Gokhan Gokalp; Cuneyt Erdogan; Mufit Parlak

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Impaired aortic distensibility in hypothyroid patients with negative coronary angiograms: Simultaneous evaluation with 128-slice multiple row detector computed tomography

机译：甲状腺功能减退的甲状腺功能减退患者的主动脉扩张性受损：128层多排探测器计算机断层扫描同时评估

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Objective To determine the relationship between arterial distensibility and hypothyroidism by simultaneous assessment of coronary angiography and aortic distensibility, measured using 128-slice retrospective electrocardiogram-gated multiple row detector computed tomography (MDCT). Methods Untreated hypothyroid patients and age-matched euthyroid patients, who underwent 128-slice retrospective electrocardiogram-gated MDCT to evaluate the coronary arteries, were assessed. Intraluminal aortic areas in systolic and diastolic phases of the cardiac cycle were measured with multiphase reformation at predefined locations including the ascending aorta, proximal descending aorta and distal descending aorta in the widest axial plane. Results The study included 21 hypothyroid and 21 euthyroid patients. Patients with hypothyroidism exhibited decreased aortic distensibility between each location in the thoracic aorta (ascending aorta, proximal descending aorta and distal descending aorta) compared with euthryoid patients. Conclusions Hypothyroidism was associated with preclinical vascular alteration, characterized by impaired aortic distensibility at each location of the thoracic aorta, which has been shown to be related to increased cardiovascular risk. Monitoring of aortic distensibility is relevant for evaluating coronary artery disease progression and treatment choices.

机译：目的通过同时评估冠状动脉造影和主动脉扩张性来确定动脉可扩张性与甲状腺功能减退的关系，该评估是使用128层回顾性心电图门控多排探测器计算机断层扫描（MDCT）测量的。方法评估未经治疗的甲状腺功能减退患者和年龄匹配的甲状腺功能正常患者，他们接受了128层回顾性心电图门控MDCT评估冠状动脉。在预定位置（包括升主动脉，近端降主动脉和远端降主动脉）在最宽的轴向平面内，通过多相再形成对心动周期收缩期和舒张期的管腔内主动脉区域进行测量。结果该研究包括21例甲状腺功能减退和21例甲状腺功能正常的患者。甲状腺功能减退的患者与类甲状腺样疾病患者相比，在主动脉的每个部位（升主动脉，近端降主动脉和远端降主动脉）之间主动脉扩张性降低。结论甲状腺功能减退症与临床前血管改变有关，其特征是胸主动脉每个部位的主动脉扩张性受损，这已被证明与心血管风险增加有关。监测主动脉扩张性与评估冠状动脉疾病进展和治疗选择有关。

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《Journal of International Medical Research》 |2013年第5期|共8页
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Abdurrahim Dusak; Gokhan Gokalp; Cuneyt Erdogan; Mufit Parlak;
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机译：肺动脉异常左冠状动脉的多排探测器计算机断层扫描冠状动脉造影图像
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机译：老年胸痛和冠状动脉造影阴性的患者冠状动脉血流储备和主动脉扩张性降低。
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机译：冠状动脉造影阴性的糖尿病患者的主动脉扩张性和冠脉流速储备降低。
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机译：用于多探测器行计算机层析成像中非线性降噪滤波器质量评估的模型
5. Cholangiography using 64-multi-detector row computed tomography in the normal dog [D] . Miller, Jennifer Wooley. 2014

机译：在普通狗中使用64位多探测器行计算机断层扫描进行胆道造影
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机译：多探测器行计算断层扫描对日本患者冠状动脉狭窄检测冠状动脉钙化的评价
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Impaired aortic distensibility in hypothyroid patients with negative coronary angiograms: Simultaneous evaluation with 128-slice multiple row detector computed tomography

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