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首页> 外文期刊>Journal of International Medical Research >Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population
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Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population

机译：中国人群中动脉粥样硬化性脑梗死与TNFSF4 / TNFRSF4单核苷酸多态性rs1234313，rs1234314和rs17568之间没有关联

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Objective To clarify the association between atherosclerotic cerebral infarction (ACI) and the single nucleotide polymorphisms (SNP) rs1234313 and rs1234314 (in TNFSF4) and rs17568 (in TNFRSF4). Methods Genomic DNA was extracted from peripheral blood of patients with ACI and healthy control subjects. The presence of carotid plaque was determined. Rs1234313, rs1234314 and rs17568 were characterized via SNP genotyping assay and verified by DNA sequencing. Results Genotype distributions were in Hardy–Weinberg equilibrium. There were no significant differences in the allele and genotype distributions of rs1234313, rs1234314 and rs17568 between patients with ACI (n?=?450) and healthy control subjects (n?=?378), or between patients with ACI and carotid plaque (n?=?342) and controls. Conclusions There were no significant associations between rs1234313, rs1234314 and rs17568 and ACI risk in a Han Chinese population.
机译：目的阐明动脉粥样硬化性脑梗死（ACI）与rs1234313和rs1234314（TNFSF4）和rs17568（TNFRSF4）的单核苷酸多态性（SNP）之间的关系。方法从ACI患者和健康对照者的外周血中提取基因组DNA。确定颈动脉斑块的存在。通过SNP基因分型分析对Rs1234313，rs1234314和rs17568进行表征，并通过DNA测序进行验证。结果基因型分布处于Hardy–Weinberg平衡状态。在ACI患者（n？=？450）和健康对照受试者（n？=？378）之间，或在ACI和颈动脉斑块（n）患者之间，rs1234313，rs1234314和rs17568的等位基因和基因型分布无显着差异。 ？=？342）和控件。结论rs1234313，rs1234314和rs17568与汉族人群的ACI风险之间没有显着相关性。

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