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首页> 外文期刊>Journal of International Medical Research >Primary prostatic extragastrointestinal stromal tumor: a case report and literature review
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Primary prostatic extragastrointestinal stromal tumor: a case report and literature review

机译：前列腺原发性胃肠道间质瘤1例并文献复习

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Objective This study was performed to discuss the characteristics, diagnosis, and treatment of primary prostatic extragastrointestinal stromal tumor (EGIST). Methods The case history data of a patient with an EGIST were analyzed and discussed with a literature review. Results The patient was diagnosed with a pelvic tumor, possibly malignant. We ascertained the diagnosis by exploratory surgery and pathological biopsy. The tumor was present in the prostate and infiltrated and pressed against the anterior rectal wall. Pathological biopsy showed that the tumor comprised spindle cells, which were also present at the junction of the tumor and prostate tissue. Immunohistochemically, the tumor cells were positive for CD117, DOG-1, CD34, and smooth muscle actin and negative for S100 and desmin; Ki-67LI was about 10%. These results support the diagnosis of primary prostatic EGIST. Conclusion The rarity and nonspecific clinical manifestation of prostatic EGIST facilitate misdiagnosis. Diagnosis mainly depends on imaging examination and characteristic histopathological and immunohistochemical features, and GIST must be excluded. Surgery is the main treatment method, and imatinib is suggested for unresectable and malignant EGISTs.
机译：目的探讨原发性前列腺外胃肠道间质瘤（EGIST）的特征，诊断和治疗。方法对EGIST患者的病历数据进行分析和讨论，并进行文献综述。结果该患者被诊断出骨盆肿瘤，可能是恶性的。我们通过探索性手术和病理活检确定了诊断。肿瘤存在于前列腺中，浸润并压迫直肠前壁。病理活检显示，肿瘤包括梭形细胞，梭形细胞也存在于肿瘤和前列腺组织的交界处。免疫组织化学分析，肿瘤细胞CD117，DOG-1，CD34和平滑肌肌动蛋白呈阳性，而S100和结蛋白呈阴性。 Ki-67LI约为10％。这些结果支持原发性前列腺癌EGIST的诊断。结论前列腺癌EGIST的罕见性和非特异性临床表现有助于误诊。诊断主要取决于影像学检查以及特征性的组织病理学和免疫组化特征，必须排除GIST。手术是主要的治疗方法，建议伊马替尼用于不可切除和恶性的EGISTs。

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