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首页> 外文期刊>Journal of International Medical Research >Serum and follicular fluid levels of sirtuin 1, sirtuin 6, and resveratrol in women undergoing in vitro fertilization: an observational, clinical study
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Serum and follicular fluid levels of sirtuin 1, sirtuin 6, and resveratrol in women undergoing in vitro fertilization: an observational, clinical study

机译：接受体外受精的女性血清sirtuin 1，sirtuin 6和白藜芦醇的血清和卵泡液水平：一项观察性临床研究

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Objective This observational, clinical study was designed to assess the role of sirtuin 1 (SIRT1), sirtuin 6 (SIRT6), and resveratrol in in vitro fertilization (IVF). Methods Paired serum and follicular fluid (FF) samples were obtained from 30 consecutive patients (age: 36.43?±?4.17 years, body mass index: 22.90?±?2.05 kg/m ~(2), duration of infertility: 5.10?±?2.80 years) who received IVF treatment. SIRT1, SIRT6, and resveratrol levels were measured by enzyme-linked immunosorbent assay. Results Ovarian hyperstimulation resulted in significantly higher serum SIRT1 levels in pregnant women (8 patients) compared with non-pregnant women (22 patients). SIRT6 levels remained unchanged after ovarian hyperstimulation, but were significantly lower in pregnant women compared with non-pregnant women before and after hyperstimulation. Both SIRTs were detected in FF, but they appeared to be independent of their serum levels. After correction for confounders, FF SIRT6 levels were positively related to mature oocytes (F?=?6.609), whereas serum SIRT1 and SIRT6 levels were related to clinical pregnancy (F?=?10.008, F?=?5.268, respectively). Conclusions Our study shows that SIRT1 and SIRT6, but not resveratrol, are involved in human reproduction and they may have a role in oocyte maturation and clinical pregnancy in IVF.
机译：目的这项观察性临床研究旨在评估瑟土因1（SIRT1），瑟土因6（SIRT6）和白藜芦醇在体外受精（IVF）中的作用。方法从30例连续患者（年龄：36.43±4.17岁，体重指数：22.90±2.05 kg / m〜（2），不孕持续时间：5.10±±）中获得配对的血清和卵泡液（FF）样本。 2.80岁）接受了IVF治疗。通过酶联免疫吸附测定法测量SIRT1，SIRT6和白藜芦醇水平。结果卵巢过度刺激导致孕妇（8例）的血清SIRT1水平显着高于未妊娠妇女（22例）。卵巢过度刺激后，SIRT6水平保持不变，但与过度刺激前后的非怀孕妇女相比，孕妇的SIRT6水平显着降低。 FF中均检测到两种SIRT，但它们似乎与血清水平无关。校正混杂因素后，FF SIRT6水平与成熟卵母细胞呈正相关（Fα=？6.609），而血清SIRT1和SIRT6水平与临床妊娠相关（Fα=？10.008，Fα=？5.268）。结论我们的研究表明，SIRT1和SIRT6参与人类生殖，但不参与白藜芦醇，它们可能在IVF的卵母细胞成熟和临床妊娠中起作用。

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