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首页> 外文期刊>Journal of International Medical Research >A Double-Blind Clinical Comparison of Two Dosage Schedules of Cefatrizine in Children
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A Double-Blind Clinical Comparison of Two Dosage Schedules of Cefatrizine in Children

机译：两种头孢他嗪剂量方案对儿童的双盲临床比较

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A double-blind, randomized clinical trial was carried out to compare the effectiveness of twice daily versus once daily administration of the cephalosporin, cefatrizine, in paediatric outpatients with bacterial infection of the respiratory tract. Thirty children were studied, aged 7 years 2 months (range, 4–-12 years). They were given 75 mg/kg·day cefatrizine either once daily or twice daily at 12 h intervals for 8 days. Fever, clinical symptoms, bacterial eradication and overall tolerance were evaluated. No significant differences were observed between once daily or twice daily administration. This is in agreement with other studies carried out on adults. It is concluded that cefatrizine may be given to paediatric out-patients for the treatment of bacterial infection of the respiratory tract only once daily with good clinical and overall results.
机译：进行了一项双盲，随机临床试验，以比较头孢菌素，头孢他嗪在患呼吸道细菌感染的小儿门诊中每日两次与每日一次的有效性。研究了30名7岁2个月（4-12岁）的儿童。每天一次或每天两次，每隔12小时给予75 mg / kg·天的头孢他利嗪，持续8天。评估发热，临床症状，根除细菌和总体耐受性。每天一次或每天两次给药之间未观察到显着差异。这与对成人进行的其他研究一致。结论是，头孢曲嗪可仅给予儿科门诊患者以治疗呼吸道细菌感染，每天一次，具有良好的临床和总体效果。

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