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首页> 外文期刊>Journal of International Medical Research >Diabetes mellitus and the risk of aneurysmal subarachnoid haemorrhage: A systematic review and meta-analysis of current evidence
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Diabetes mellitus and the risk of aneurysmal subarachnoid haemorrhage: A systematic review and meta-analysis of current evidence

机译：糖尿病与动脉瘤性蛛网膜下腔出血的风险：对当前证据的系统评价和荟萃分析

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Objective This systematic review aimed to define the relationship between diabetes mellitus (DM) and the risk of aneurysmal subarachnoid haemorrhage (aSAH). Methods Studies associated with DM and aSAH published until March 2016 were retrieved from Pubmed, Embase, Web of Science, and Cochrane Library databases. A random-effects model was used to calculate the relative risks (RRs) with 95% confidence intervals (CIs). Results Eighteen observational studies were retrieved. The overall RRs for DM and aSAH were RRs?=?0.59 (0.44, 0.79), with moderate heterogeneity ( I ~(2?)=?55.7%, P _(heterogeneity)?=?0.000). Subgroup analysis by study quality revealed a reduced association between DM and aSAH risk in high quality studies only (RRs?=?0.40, 95% CI: 0.29, 0.56; I ~(2?)=?0.0%, P _(heterogeneity)?=?0.549), therefore study quality may be a source of heterogeneity. Conclusion A potential decreased risk of aSAH in DM patients was found in high quality studies. Further studies are required to confirm this causal relationship and to investigate the biological mechanisms.
机译：目的本系统评价旨在确定糖尿病（DM）与动脉瘤性蛛网膜下腔出血（aSAH）风险之间的关系。方法从Pubmed，Embase，Web of Science和Cochrane Library数据库中检索到2016年3月为止与DM和aSAH相关的研究。随机效应模型用于计算具有95％置信区间（CI）的相对风险（RR）。结果共检索到18项观察性研究。 DM和aSAH的总RR为RRs = = 0.59（0.44，0.79），具有中等程度的异质性（I〜（2？）=？55.7％，P_（异质性）？=？0.000）。通过研究质量进行的亚组分析显示，仅在高质量研究中，DM和aSAH风险之间的关联性降低了（RRs？=？0.40，95％CI：0.29，0.56; I〜（2？）=？0.0％，P _（异质性） ？=？0.549），因此研究质量可能是异质性的来源。结论在高质量研究中发现DM患者潜在的aSAH风险降低。需要进一步的研究以确认这种因果关系并研究生物学机制。

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