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首页> 外文期刊>Journal of International Medical Research >The SURMetaGIT study: Design and rationale for a prospective pan-omics examination of the gastrointestinal response to Roux-en-Y gastric bypass surgery
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The SURMetaGIT study: Design and rationale for a prospective pan-omics examination of the gastrointestinal response to Roux-en-Y gastric bypass surgery

机译：SURMetaGIT研究：针对Roux-en-Y胃搭桥手术胃肠道反应的前瞻性泛组学检查的设计和原理

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Objective To describe the protocol of the SUR gically induced Meta bolic effects on the Human G astro I ntestinal T ract (SURMetaGIT) study, a clinical pan-omics study exploring the gastrointestinal tract as a central organ driving remission of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGB). The main points considered in the study’s design and challenges faced in its application are detailed. Methods This observational, longitudinal, prospective study involved collection of gastrointestinal biopsy specimens, faeces, urine, and blood from 25 obese women with T2DM who were candidates for RYGB (20 patients for omics assessment and 5 for omics validation). These collections were performed preoperatively and 3 and 24 months postoperatively. Gastrointestinal transcriptomics; faecal metagenomics and metabolomics; plasma proteomics, lipidomics, and metabolomics; and biochemical, nutritional, and metabolic data were assessed to identify their short- and long-term correlations with T2DM remission. Results Data were collected from 20 patients before and 3 months after RYGB. These patients have nearly completed the 2-year follow-up assessments. The five additional patients are currently being selected for omics data validation. Conclusion The multi-integrated pan-omics approach of the SURMetaGIT study enables integrated analysis of data that will contribute to the understanding of molecular mechanisms involved in T2DM remission after RYGB.
机译：目的描述SUR诱导的代谢作用对人类胃肠道研究（SURMetaGIT）的协议，SURMetaGIT是一项临床全组学研究，探索胃肠道是驱动2型糖尿病（T2DM）缓解的中心器官）进行Roux-en-Y胃旁路手术（RYGB）后。详细介绍了研究设计中要考虑的要点以及应用中面临的挑战。方法这项观察性，纵向，前瞻性研究涉及从25例RYGB的肥胖T2DM肥胖妇女中收集胃肠道活检标本，粪便，尿液和血液（20例进行组学评估，5例进行组学验证）。这些收集是在术前以及术后3和24个月进行的。胃肠道转录组学;粪便宏基因组学和代谢组学;血浆蛋白质组学，脂质组学和代谢组学;评估生化，营养和代谢数据，以确定它们与T2DM缓解的短期和长期相关性。结果数据来自RYGB之前和之后3个月的20例患者。这些患者几乎完成了2年的随访评估。当前正在选择另外五名患者进行组学数据验证。结论SURMetaGIT研究的多集成体全基因组学方法能够对数据进行集成分析，这将有助于了解RYGB后T2DM缓解所涉及的分子机制。

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