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首页> 外文期刊>Journal of International Medical Research >Serum melatonin levels are associated with mortality in patients with malignant middle cerebral artery infarction
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Serum melatonin levels are associated with mortality in patients with malignant middle cerebral artery infarction

机译：血清中褪黑激素水平与恶性脑中动脉梗死患者的死亡率相关

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Objectives Lower serum melatonin levels are found in patients with ischaemic stroke compared with healthy controls. This study aimed to determine whether serum melatonin levels are associated with peroxidation status, antioxidant status, and mortality in patients with ischaemic stroke. Methods Patients with severe malignant middle cerebral artery infarction (MMCAI), defined as a Glasgow coma scale (GCS) score lower than 9, were included. Serum levels of melatonin, malondialdehyde (to assess lipid peroxidation), and total antioxidant capacity at the time of diagnosing MMCAI were determined. We chose 30-day mortality as the endpoint of the study. Results We found significantly higher serum levels of melatonin, total antioxidant capacity, and malondialdehyde in non-survivors (n?=?32) than in survivors (n?=?32) with MMCAI. Serum melatonin levels were associated with 30-day mortality (odds ratio?=?2.205; 95% confidence interval?=?1.294–3.759) after controlling for GCS score and age. We found a positive association between serum melatonin levels and total antioxidant capacity (rho?=?0.36), and between serum melatonin and malondialdehyde levels (rho?=?0.35). Conclusions Our study shows that serum melatonin levels are associated with peroxidation status, antioxidant status, and mortality in patients with MMCAI.
机译：目的与健康对照组相比，缺血性中风患者的血清褪黑激素水平较低。这项研究旨在确定血清褪黑激素水平是否与缺血性中风患者的过氧化状态，抗氧化剂状态和死亡率相关。方法纳入严重格拉斯哥昏迷量表（GCS）评分低于9分的严重恶性大脑中动脉梗塞（MMCAI）患者。在诊断MMCAI时，测定了血清褪黑激素，丙二醛（以评估脂质过氧化作用）和总抗氧化能力。我们选择30天死亡率作为研究的终点。结果我们发现，非存活者（n≥32）的血清褪黑激素，总抗氧化能力和丙二醛水平明显高于MMCAI存活者（n≥32）。在控制GCS评分和年龄后，血清褪黑激素水平与30天死亡率相关（奇数比== 2.205; 95％置信区间== 1.294-3.759）。我们发现血清褪黑激素水平与总抗氧化能力之间呈正相关（rho≥0.36），血清褪黑激素与丙二醛水平之间呈正相关（rho≥0.35）。结论我们的研究表明，血清褪黑激素水平与MMCAI患者的过氧化状态，抗氧化剂状态和死亡率相关。

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