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首页> 外文期刊>Journal of International Medical Research >A Comparative Trial of Depot Pipothiazine
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A Comparative Trial of Depot Pipothiazine

机译：储库哌嗪的比较试验

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Thirty-nine chronic schizophrenic patients were selected for a 12-month double-blind evaluation of the effectiveness of pipothiazine palmitate (PPT) and flupenthixol decanoate (FPX) in the maintenance management of their illness. Allocation was at random and, in order to allow constant injection intervals, the patients typically received every 2 weeks either 40 mg of flupenthixol decanoate or alternating injections of 100 mg of pipothiazine palmitate and placebo. At monthly intervals the patients were assessed using both a battery of rating scales (which included the Brief Psychiatric Rating Scale (BPRS), the Extrapyramidal Symptoms Rating Scale (EPS)) and a general side-effects evaluation. At 3-monthly intervals they were also rated on the Comprehensive Psychiatric Rating Scale (CPRS) and the Zung Depression Scale. Haematological and biochemical tests were performed every 3 months. Both drugs provided good control of psychotic symptoms and side-effects were not troublesome. No substantial difference was detected on the CPRS and the Zung scales. There was a trend in favour of PPT on the BPRS survey, detectable at 6 months and reaching statistical significance by 12 months. We conclude that the PPT regime is at least as effective as the FPX treatment and probably more so. It is possible that even longer periods of control could be obtained with PPT.
机译：选择了39例慢性精神分裂症患者，进行了为期12个月的双盲评估，评估了棕榈酸哌妥嗪（PPT）和癸酸氟喷他醇（FPX）在维持疾病治疗中的有效性。分配是随机的，并且为了允许恒定的注射间隔，患者通常每2周接受40 mg癸酸氟喷他醇或100 mg棕榈酸哌妥嗪和安慰剂交替注射。在每月的时间间隔内，使用一系列的评定量表（包括简短的精神病学评定量表（BPRS），锥体外系症状评定量表（EPS））和一般的副作用评估对患者进行评估。每三个月对他们进行一次综合精神病评定量表（CPRS）和抑郁症量表的评定。每3个月进行血液和生化检查。两种药物都能很好地控制精神病症状，而且副作用并不麻烦。在CPRS和Zung量表上未检测到实质性差异。在BPRS调查中，倾向于PPT的趋势是在6个月时可检测到，并在12个月时达到统计学意义。我们得出的结论是，PPT方案至少与FPX治疗一样有效，并且可能更有效。 PPT可能获得更长的控制时间。

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