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首页> 外文期刊>Journal of King Saud University >N-Acetylcysteine reduces the neurotoxic effects of propionic acid in rat pups
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N-Acetylcysteine reduces the neurotoxic effects of propionic acid in rat pups

机译：N-乙酰半胱氨酸降低丙酸对大鼠幼崽的神经毒性作用

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Propionic acid, a metabolite produced by intestinal bacteria, has been implicated in autism. N-Acetylcysteine is a well-known antioxidant. The present study investigated the protective effects of N-Acetylcysteine on propionic acid-induced neurotoxicity in rat pups. Male Western albino rats were divided into four groups. The first group served as the normal control group, the second was treated with propionic acid (PA group), the third group received propionic acid followed by N-Acetylcysteine (PANA group), and the fourth group received N-Acetylcysteine followed by propionic acid (NAPA group). In the PA group, there was a significant increase in lactate dehydrogenase activity, decrease in glutathione levels, and decrease in sodium levels ( P 0.05, all comparisons). Calcium and potassium levels did not significantly change. Additionally, urea and lipid peroxide levels were significantly elevated in propionic acid-intoxicated rats and significantly rescued in the N-Acetylcysteine-treated groups ( P 0.05, all comparisons). These results indicate that N-Acetylcysteine can both protect against and treat propionic acid intoxication.
机译：丙酸是肠道细菌产生的代谢产物，与自闭症有关。 N-乙酰半胱氨酸是众所周知的抗氧化剂。本研究调查了N-乙酰半胱氨酸对丙酸诱导的幼鼠神经毒性的保护作用。将雄性西部白化病大鼠分为四组。第一组为正常对照组，第二组接受丙酸治疗（PA组），第三组接受丙酸治疗，然后接受N-乙酰半胱氨酸（PANA组），第四组接受N-乙酰半胱氨酸治疗，然后接受丙酸（NAPA组）。在PA组，乳酸脱氢酶活性显着增加，谷胱甘肽水平降低，而钠水平降低（P <0.05，所有比较）。钙和钾水平没有明显变化。此外，在丙酸中毒的大鼠中尿素和脂质过氧化物水平显着升高，在经N-乙酰半胱氨酸治疗的组中明显得到挽救（P <0.05，所有比较）。这些结果表明，N-乙酰半胱氨酸既可以预防丙酸中毒，又可以治疗丙酸中毒。

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