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首页> 外文期刊>Journal of International Medical Research >Clinical Outcomes of Ovulation Induction with Metformin, Clomiphene Citrate and Human Menopausal Gonadotrophin in Polycystic Ovary Syndrome
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Clinical Outcomes of Ovulation Induction with Metformin, Clomiphene Citrate and Human Menopausal Gonadotrophin in Polycystic Ovary Syndrome

机译：二甲双胍，枸Clo酸克罗米芬和人类更年期促性腺激素诱导排卵在多囊卵巢综合征中的临床结果

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This pilot study evaluated the effects of coadministration of metformin with clomiphene citrate (CC) and human menopausal gonadotrophin (HMG) in women with CC-resistant polycystic ovary syndrome (PCOS). Sixty women with PCOS were randomly assigned to receive 3 months' treatment with metformin or placebo together with CC and HMG. Transvaginal ultrasound was used to monitor follicular development and ovulation was induced by human chorionic gonadotrophin (HCG). The number of dominant follicles, the oestradiol level on the day HCG was given and the amount of HMG required were significantly lower in the metformin group than in the placebo group, whereas the mono-ovulatory rate and pregnancy rate in the third cycle were significantly higher. The cumulative pregnancy rate in the metformin group (43.3%) was higher than in the placebo group (20.0%), but this difference did not reach statistical significance. In conclusion, coadministration of metformin with CC and HMG reduced the amount of HMG required and increased the mono-ovulatory rate and pregnancy rate.
机译：这项初步研究评估了二甲双胍与柠檬酸克罗米芬（CC）和人类更年期促性腺激素（HMG）并用对CC耐药的多囊卵巢综合征（PCOS）妇女的影响。 60名患有PCOS的妇女被随机分配接受二甲双胍或安慰剂以及CC和HMG的3个月治疗。经阴道超声监测卵泡的发育，并由人绒毛膜促性腺激素（HCG）诱导排卵。与安慰剂组相比，二甲双胍组显性卵泡数目，HCG当天的雌二醇水平和所需的HMG量均显着低于安慰剂组，而第三周期的单排卵率和妊娠率则明显高于安慰剂组。 。二甲双胍组（43.3％）的累积妊娠率高于安慰剂组（20.0％），但这一差异没有统计学意义。总之，将二甲双胍与CC和HMG并用可减少所需的HMG量并增加单排卵率和妊娠率。

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