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首页> 外文期刊>Journal of International Medical Research >Household Transmission of Influenza (H1N1-2009) in Japan: Age-Specificity and Reduction of Household Transmission Risk by Zanamivir Treatment
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Household Transmission of Influenza (H1N1-2009) in Japan: Age-Specificity and Reduction of Household Transmission Risk by Zanamivir Treatment

机译：日本的家庭流感传播（H1N1-2009）：年龄特异性和扎那米韦治疗减少家庭传播风险

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This study investigated household transmission data for influenza (H1N1-2009) in Japan in order to quantify the age-specific risk of infection and estimate the impact of antiviral treatment on the risk of household transmission. Among a total of 1547 households, involving 4609 household contacts, the secondary attack ratio (SAR) was estimated to be 11.4%. School children aged 5 – 18 years dominated the index cases. Age-specific infectiousness and susceptibility were highest among 0 – 4-year olds, with SAR estimated at 19.4% and 29.6%, respectively. Zanamivir treatment within 24 and 24 – 48 h of illness onset in index cases, respectively, reduced the risk of household transmission to 0.57 (95% CI 0.44, 0.73) and 0.58 (95% CI 0.38, 0.86) times that among those receiving the same treatment at > 48 h and those not receiving treatment. The preventive performance of antiviral treatment and prophylaxis should be further examined in randomized controlled trials.
机译：这项研究调查了日本流行性感冒（H1N1-2009）的家庭传播数据，以便量化特定年龄段的感染风险，并估计抗病毒治疗对家庭传播风险的影响。在涉及4609个家庭联系的1547户家庭中，二次攻击率（SAR）估计为11.4％。 5至18岁的小学生占主导地位。年龄特定的传染性和易感性在0至4岁的人群中最高，SAR分别估计为19.4％和29.6％。在指标病例中，扎那米韦在发病后24和24-48 h内的治疗分别将家庭传播的风险降低到接受该药物治疗者的0.57倍（95％CI 0.44，0.73）和0.58（95％CI 0.38，0.86）。在48小时以上未接受治疗的患者均接受同样的治疗。在随机对照试验中应进一步检查抗病毒治疗的预防性能和预防措施。

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