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首页> 外文期刊>Journal of International Medical Research >The Effects of Adjuvant Immunoglobulin M-Enriched Immunoglobulin Therapy on Mortality Rate and Renal Function in Sepsis-Induced Multiple Organ Dysfunction Syndrome: Retrospective Analysis of Intensive Care Unit Patients
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The Effects of Adjuvant Immunoglobulin M-Enriched Immunoglobulin Therapy on Mortality Rate and Renal Function in Sepsis-Induced Multiple Organ Dysfunction Syndrome: Retrospective Analysis of Intensive Care Unit Patients

机译：脓毒症诱发的多器官功能障碍综合症辅助免疫球蛋白M含量增加对死亡率和肾功能的影响：重症监护病房患者的回顾性分析

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OBJECTIVE: To determine the effect of immunoglobulin (Ig)M-enriched Ig therapy on mortality rate and renal function in sepsis-induced multiple organ dysfunction syndrome (MODS), using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. METHODS: Retrospective study of patients with sepsis-induced MODS treated with standard antibiotic plus supportive therapy (control group) or IgM-enriched Ig therapy adjuvant to control group therapy (IVIg group). Total length of stay in the intensive care unit (ICU), overall mortality rate and 28-day case fatality rate (CFR), as well as APACHE II scores and renal function parameters at day 1 and day 4 of therapy, were recorded. RESULTS: A total of 118 patients were included (control group, n = 62; IVIg group, n = 56). In both groups, day 4 APACHE II scores decreased significantly compared with day 1 scores; the effect of treatment on renal function was minimal. Length of ICU stay, overall mortality rate and 28-day CFR were significantly lower in the IVIg group compared with the control group. CONCLUSIONS: Adding IgM-enriched Ig therapy to standard therapy for MODS improved general clinical conditions and significantly reduced APACHE II scores, overall mortality rate and 28-day CFR, although effects on renal function were minimal.
机译：目的：使用急性生理和慢性健康评估II（APACHE II）评分，确定富含免疫球蛋白（Ig）M的Ig治疗对败血症诱发的多器官功能障碍综合征（MODS）的死亡率和肾功能的影响。方法：回顾性研究脓毒症诱发MODS的患者接受标准抗生素加支持疗法（对照组）或富含IgM的Ig疗法作为对照组（IVIg组）的辅助治疗。记录在治疗的第1天和第4天在重症监护病房（ICU）的总住院时间，总死亡率和28天病死率（CFR）以及APACHE II评分和肾功能参数。结果：共纳入118例患者（对照组，n = 62; IVIg组，n = 56）。在两组中，第4天的APACHE II分数均比第1天的分数显着降低。治疗对肾功能的影响微乎其微。与对照组相比，IVIg组的ICU住院时间，总死亡率和28天CFR显着降低。结论：在MODS的标准疗法中添加富含IgM的Ig疗法可改善一般临床状况，并显着降低APACHE II评分，总死亡率和28天病死率，尽管对肾脏功能的影响微乎其微。

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