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首页> 外文期刊>Journal of International Medical Research >Amniotic fluid oxidant–antioxidant status in foetal congenital nervous system anomalies
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Amniotic fluid oxidant–antioxidant status in foetal congenital nervous system anomalies

机译：胎儿先天性神经系统异常中羊水的氧化-抗氧化状态

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Objective This study aimed to evaluate the oxidant–antioxidant status of amniotic fluid in pregnant women with foetal congenital malformations of the central nervous system. Methods We studied pregnant women with foetal congenital nervous system anomalies at 16–22 weeks’ gestation (n?=?36). The control group (n?=?30) consisted of pregnant women at the same gestational age who underwent amniocentesis, resulting in a normal karyotype. We analysed glutathione, catalase, and malondialdehyde levels in amniotic fluid. Enzyme activation was measured by spectrophotometry. Results The demographic features of the groups were similar in terms of age, parity, body mass index, and gestational weeks. We detected lower glutathione and catalase levels in the foetal congenital anomaly group than in the control group. We detected higher malondialdehyde levels in the foetal congenital anomaly group than in the control group. Conclusion In the organism, the rate of formation of free radicals and their rate of removal are balanced, and this is called oxidative balance. As long as oxidative stability is achieved, the organism is not affected by free radicals. This fact should be kept in mind to avoid any type of teratogenic agent that could lead to congenital disorders.
机译：目的本研究旨在评估患有胎儿先天性中枢神经系统畸形的孕妇羊水的氧化-抗氧化状态。方法我们研究了妊娠16-22周时胎儿先天性神经系统异常的孕妇（n？=？36）。对照组（n≥30）由相同胎龄的孕妇进行羊膜穿刺术，导致正常的核型。我们分析了羊水中的谷胱甘肽，过氧化氢酶和丙二醛水平。酶活化通过分光光度法测量。结果两组的人口统计学特征在年龄，胎次，体重指数和孕周方面相似。我们发现胎儿先天性异常组的谷胱甘肽和过氧化氢酶水平低于对照组。我们发现胎儿先天性异常组的丙二醛水平高于对照组。结论在生物体中，自由基的形成速率和清除速率是平衡的，这称为氧化平衡。只要达到氧化稳定性，该生物就不受自由基的影响。应当牢记这一事实，以避免可能导致先天性疾病的任何致畸剂。

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