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首页> 外文期刊>Journal of International Medical Research >Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits
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Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits

机译：志甘草汤对新西兰兔快速起搏心房颤动模型心肌纤维化的逆转作用

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Objective To evaluate the effect of Zhigancao decoction on reversal of right atrial myocardial fibrosis after rapid atrial pacing (RAP)-induced atrial fibrillation (AF). Methods New Zealand white rabbits were randomly divided into four groups: sham operation group (Group A: implanted electrodes, no RAP), pacing group (Group B: RAP-induced AF), Zhigancao soup water decoction Yin group (Group C: RAP-induced AF followed by Zhigancao soup Yin prescription twice a day for 30 days), and Zhigancao soup group (Group D: RAP-induced AF followed by Zhigancao water decoction twice a day for 30 days). The atrial myocardium was then examined for myocardial fibrosis by Masson staining, and protein expression of matrix metalloproteinase-9 (MMP-9) was immunohistochemically assessed. The right atrial appendage tissue field action potential duration (fAPD) was measured by microelectrode arrays. Results RAP successfully induced AF. Myocardial fibrosis was more severe in Groups B and C and less severe in Group D. Protein expression of MMP-9 was strongly positive in Groups B and C and weakly positive in Group D. The fAPD was significantly decreased in Groups B and C, but the decrease in Group D was not significant. Conclusion Zhigancao decoction can reverse AF-induced myocardial fibrosis in rabbits and shorten the fAPD.
机译：目的评价知心草汤对快速心房起搏（RAP）诱发心房纤颤（AF）后右心房肌纤维化的逆转作用。方法将新西兰大白兔随机分为四组：假手术组（A组：植入电极，无RAP），起搏组（B组：RAP诱导的AF），止肝草汤水煎阴组（C组：RAP-）。诱导性房颤，然后每日两次两次服用知干草汤阴，持续30天），以及知干草汤组（D组：RAP诱导的房颤，然后每天两次进行知干草水煎汤，持续30天）。然后通过Masson染色检查心房心肌纤维化，并通过免疫组织化学方法评估基质金属蛋白酶9（MMP-9）的蛋白表达。通过微电极阵列测量右心耳组织场动作电位持续时间（fAPD）。结果RAP成功诱发房颤。 B和C组心肌纤维化更严重，D组不严重。MMP-9的蛋白表达在B和C组中强阳性，在D组中弱阳性。fAPD在B和C组中显着降低，但D组的减少并不明显。结论止gan草汤可逆转房颤诱发的家兔心肌纤维化，缩短fAPD。

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