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首页> 外文期刊>Journal of Investigative Dermatology Symposium Proceedings >Biological Functions of Keratinocyte Cholinergic Receptors
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Biological Functions of Keratinocyte Cholinergic Receptors

机译：角质形成胆碱能受体的生物学功能

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Human epidermal keratinocytes possess cholinergic enzymes, which synthesize and degrade acetylcholine, and express both nicotinic and muscarinic classes of cholinergic receptors on their cell surfaces. These receptors bind acetylcholine and initiate cellular response. The presence in keratinocytes of a functional cholinergic system suggests a role for acetylcholine in most, if not all, aspects of keratinocyte function. Autocrine and paracrine acetylcholine are required to sustain the viability of keratinocytes in vitro, and cholinergic drugs can alter keratinocyte proliferation, adhesion, migration, and differentiation. Acetylcholine employs calcium as a mediator for its effects on keratinocytes. In turn, changes in calcium concentration may affect expression and function of keratinocyte cholinergic enzymes and cholinergic receptors. At different stages of their differentiation, keratinocytes may demonstrate unique combinations of cholinergic enzymes and cholinergic receptor types. This would allow basal, prickle, and granular keratinocytes to respond to acetylcholine differently, in accordance with their functions at each stage of keratinocyte development in epidermis. Journal of Investigative Dermatology Symposium Proceedings 2:41–48, 1997
机译：人表皮角质形成细胞具有胆碱能酶，该酶合成和降解乙酰胆碱，并在其细胞表面表达烟碱类和毒蕈碱类胆碱能受体。这些受体结合乙酰胆碱并启动细胞反应。功能性胆碱能系统在角质形成细胞中的存在表明乙酰胆碱在大多数（如果不是全部）角质形成细胞功能方面发挥作用。需要自分泌和旁分泌的乙酰胆碱来维持体外角质形成细胞的活力，胆碱能药物可以改变角质形成细胞的增殖，粘附，迁移和分化。乙酰胆碱利用钙作为介导其对角质形成细胞的作用。反过来，钙浓度的变化可能会影响角质形成细胞胆碱能酶和胆碱能受体的表达和功能。在其分化的不同阶段，角质形成细胞可能表现出胆碱能酶和胆碱能受体类型的独特组合。根据它们在表皮角质形成细胞发展的各个阶段的功能，这将使基底，痒和颗粒状角质形成细胞对乙酰胆碱的反应不同。皮肤病学研究研讨会论文集2：41–48，1997

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