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首页> 外文期刊>Journal of King Saud University >Identification of bioactive compounds in leaf extract of Avicennia alba by GC-MS analysis and evaluation of its in-vitro anticancer potential against MCF7 and HeLa cell lines
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Identification of bioactive compounds in leaf extract of Avicennia alba by GC-MS analysis and evaluation of its in-vitro anticancer potential against MCF7 and HeLa cell lines

机译：GC-MS鉴定 Alvicennia alba 叶提取物中的生物活性化合物并评估其对MCF7和HeLa细胞系的体外抗癌能力

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摘要

The current study focused on GC-MS analysis for identification of bioactive compounds in leaf extract of mangrove plant,Avicennia albaand the leaf extract ofAvicennia albawas tested for cytotoxicity against MCF 7 and HeLa cell lines. The spectral properties (GC-MS) of each separated compound were determined and found the different compounds namely terpenoids, di-terpene alcohols, tri-terpenes and phenolic compounds. GC-MS analysis proved that the leaf extract ofAvicennia albacontain a high content of phenolic compounds. The methanol extract showed potent cytotoxicity against Human breastadeno carcinoma (MCF7) and HeLa cell lines, the viability of cancerous cells is reduced to 44.68% for MCF 7 and 35.89% for HeLa cells. The high anticancer activity was found against HeLa cell lines than MCF 7 cell lines.
机译：目前的研究侧重于GC-MS分析，以鉴定红树林植物，白叶蝉和白头翁的叶提取物中的生物活性化合物，并测试了其对MCF 7和HeLa细胞系的细胞毒性。测定每种分离的化合物的光谱特性（GC-MS），发现不同的化合物，即萜类，二萜醇，三萜和酚类化合物。 GC-MS分析证明白叶刺槐的叶提取物含有高含量的酚类化合物。甲醇提取物显示出对人乳腺癌细胞（MCF7）和HeLa细胞系的有效细胞毒性，癌细胞的存活率对于MCF 7降低至44.68％，对于HeLa细胞降低至35.89％。发现对HeLa细胞系的抗癌活性比MCF 7细胞系高。

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