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首页> 外文期刊>Journal of International Medical Research >Efficacy and Safety of Barnidipine Compared with Felodipine in the Treatment of Hypertension in Chinese Patients
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Efficacy and Safety of Barnidipine Compared with Felodipine in the Treatment of Hypertension in Chinese Patients

机译：巴尼地平与非洛地平治疗中国高血压的疗效和安全性

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The efficacy and safety profiles of barnidipine in the treatment of hypertension were evaluated in an open parallel-group study. Fifty-nine Chinese patients with mild-to-moderate essential hypertension were randomized to receive either barnidipine or felodipine (5 mg once daily, titrated to 10 mg or 15 mg once daily, as indicated) for 12 weeks. Both drugs reduced blood pressures significantly with ≥ 68% of cases obtaining marked or moderate blood pressure reduction. Mean reductions in systolic and diastolic blood pressure for barnidipine treatment were 23.7 ± 13.5 mmHg and 12.7 ± 7.9 mmHg, and for felodipine, 24.3 ± 18.4 mmHg and 14.5 ± 10.0 mmHg, respectively. There was no significant difference between these two drugs in anti-hypertensive effect, heart rate, laboratory measurements or incidence of adverse events. The only difference was that more patients taking felodipine experienced palpitations. We conclude that barnidipine has similar efficacy and a similar safety profile to felodipine in the treatment of mild-to-moderate essential hypertension in Chinese patients.
机译：一项公开平行组研究评估了巴尼地平治疗高血压的疗效和安全性。五十九名患有轻度至中度原发性高血压的中国患者被随机分配接受巴尼地平或非洛地平（如所示每日一次5毫克，如所示，每天滴定至10毫克或15毫克），持续12周。两种药物均能显着降低血压，≥68％的患者获得明显或中等程度的血压降低。巴尼地平治疗的收缩压和舒张压平均降低分别为23.7±13.5 mmHg和12.7±7.9 mmHg，非洛地平分别为24.3±18.4 mmHg和14.5±10.0 mmHg。两种药物在抗高血压作用，心率，实验室测量或不良事件发生率方面无显着差异。唯一的区别是，服用非洛地平的更多患者出现心pal。我们得出的结论是，巴尼地平在治疗中度至中度原发性高血压中与非洛地平具有相似的疗效和安全性。

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