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首页> 外文期刊>Journal of International Medical Research >A Clinical Pilot Study of Fresh Frozen Plasma versus Human Albumin in Paediatric Craniofacial Repair
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A Clinical Pilot Study of Fresh Frozen Plasma versus Human Albumin in Paediatric Craniofacial Repair

机译：新鲜冷冻血浆与人白蛋白在小儿颅面修复中的临床试验研究

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Paediatric craniofacial surgery (pCFS) regularly requires transfusion of packed red blood cells (pRBC). In this clinical pilot study two different transfusion regimens were prospectively compared concerning pRBC transfusions, postoperative bleeding and other clinical parameters. Thirty infants (aged < 12 months) scheduled for pCFS were assigned to receive fresh frozen plasma (FFP-group, n = 15) or 5% human albumin (HA-group, n = 15) during the entire surgical procedure. Perioperative amounts of pRBC, postoperative bleeding, major complications, duration of stay in the intensive care unit and overall hospital stay were compared. Differences in pRBC transfusions, postoperative bleeding, and duration of intensive care unit stay were not significant and no major complications occurred in either group. A significantly shorter overall hospital stay was observed in favour of the FFP-group. Volume replacement during pCFS can be safely performed with both applied protocols. Our data do not demonstrate a major advantage for FFP use, but further evaluation is necessary.
机译：小儿颅面外科手术（pCFS）通常需要输注堆积的红细胞（pRBC）。在这项临床试验研究中，前瞻性比较了两种不同的输血方案，涉及pRBC输血，术后出血和其他临床参数。计划进行pCFS的30例婴儿（年龄<12个月）在整个手术过程中接受新鲜的冷冻血浆（FFP组，n = 15）或5％人白蛋白（HA组，n = 15）。比较了围手术期的pRBC量，术后出血，主要并发症，重症监护病房的住院时间和整体住院时间。在两组中，pRBC输血，术后出血和重症监护病房住院时间的差异均不显着，并且没有发生重大并发症。观察到FFP组的总体住院时间明显缩短。可以通过两种应用协议安全地执行pCFS期间的卷替换。我们的数据并未显示出使用FFP的主要优势，但需要进一步评估。

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