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首页> 外文期刊>Journal of International Medical Research >The Diagnostic Utility of Maspin in the Distinction between Malignant Mesothelioma and Pulmonary Adenocarcinoma
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The Diagnostic Utility of Maspin in the Distinction between Malignant Mesothelioma and Pulmonary Adenocarcinoma

机译：Maspin对恶性间皮瘤和肺腺癌的诊断价值

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Immunohistochemistry is frequently employed to differentiate between malignant mesothelioma (MM) and pulmonary adenocarcinoma (AC) infiltrating the pleura, but there is uncertainty as to which antibodies are most useful. The present study investigated the presence of the serine protease, maspin, in epithelioid MMs and evaluated the diagnostic utility of maspin for the differential diagnosis between epithelioid MM and pulmonary AC with pleural involvement. The results showed more frequent maspin immunostaining among AC cases compared with MM cases. Maspin positivity was significantly higher among AC cases with respect to both the extent and intensity of staining. A significant difference also existed between the two tumour types with respect to the overall maspin score. Despite these findings, the sensitivity and specificity of maspin positivity to detect AC were only 59% and 73%, respectively, indicating that detection of maspin is of no value for the differential diagnosis of AC and MM.
机译：免疫组织化学常用于区分浸润胸膜的恶性间皮瘤（MM）和肺腺癌（AC），但尚不确定哪种抗体最有用。本研究调查了丝氨酸蛋白酶maspin在上皮样MM中的存在，并评价了maspin在上皮样MM和胸膜累及肺部AC之间的鉴别诊断价值。结果表明，与MM病例相比，AC病例中maspin免疫染色的频率更高。在AC病例中，就染色的程度和强度而言，Maspin阳性显着更高。就总体maspin评分而言，两种肿瘤类型之间也存在显着差异。尽管有这些发现，但是Maspin阳性检测AC的敏感性和特异性分别仅为59％和73％，这表明Maspin检测对于AC和MM的鉴别诊断没有价值。

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