Inverse Correlation between CD4+CD25HighCD127low/? Regulatory T-Cells and Serum Immunoglobulin A in Patients with New-Onset Ankylosing Spondylitis

S-S Zhao; J-W Hu; J Wang; X-J Lou; L-L Zhou

首页> 外文期刊>Journal of International Medical Research >Inverse Correlation between CD4+CD25HighCD127low/? Regulatory T-Cells and Serum Immunoglobulin A in Patients with New-Onset Ankylosing Spondylitis

【24h】

Inverse Correlation between CD4+CD25HighCD127low/? Regulatory T-Cells and Serum Immunoglobulin A in Patients with New-Onset Ankylosing Spondylitis

机译：CD4 + CD25HighCD127low /？之间的反相关新型强直性脊柱炎患者的调节性T细胞和血清免疫球蛋白A

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

This study investigated the role of regulatory T (Treg) cells in patients with new-onset, treatment-na?ve ankylosing spondylitis (AS). Levels of CD4+CD25highCD127low/- Treg cells in the peripheral blood of 14 AS patients and 18 age-matched healthy volunteers were investigated by flow cytometry and correlations with serum levels of immunoglobulin A (IgA) and AS activity, as assessed by the Bath AS Disease Activity Index (BASDAI), were analysed. The number of peripheral blood CD4+CD25highCD127low/- Treg cells in AS patients was found to be significantly lower than in healthy controls and was inversely correlated with serum IgA levels. There was no significant correlation between CD4+CD25highCD127low/- Treg cell numbers and BASDAI scores. It is concluded that CD4+CD25highCD127low/-Treg cells may play a role in the pathogenesis and activity of AS.

机译：这项研究调查了调节性T（Treg）细胞在新发，初治性强直性脊柱炎（AS）患者中的作用。通过流式细胞术研究了14名AS患者和18名年龄匹配的健康志愿者外周血中CD4 + CD25highCD127low /-Treg细胞的水平，并通过Bath AS评估了其与血清免疫球蛋白A（IgA）和AS活性的相关性分析疾病活动指数（BASDAI）。发现AS患者的外周血CD4 + CD25highCD127low /-Treg细胞数量显着低于健康对照组，并且与血清IgA水平呈负相关。 CD4 + CD25highCD127low /-Treg细胞数量与BASDAI得分之间无显着相关性。结论：CD4 + CD25highCD127low / -Treg细胞可能在AS的发病机理和活动中起作用。

著录项

来源
《Journal of International Medical Research》 |2011年第5期|共7页
作者
S-S Zhao; J-W Hu; J Wang; X-J Lou; L-L Zhou;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial [J] . Agnes Hartl, Joachim Sieper, Uta Syrbe, Arthritis research & therapy. . 2017,第1期

机译：强直性脊柱炎患者的血清瘦素和高分子量脂联素水平与影像学脊髓发育呈负相关：ENRADAS试验结果
2. Inverse correlation of programmed death 1 (PD-1) expression in T cells to the spinal radiologic changes in Taiwanese patients with ankylosing spondylitis. [J] . Chen MH, Chen WS, Lee HT, Clinical rheumatology . 2011,第9期

机译：台湾强直性脊柱炎患者中T细胞中程序性死亡1（PD-1）表达与脊髓放射学变化呈负相关。
3. Inverse correlation of programmed death 1 (PD-1) expression in T cells to the spinal radiologic changes in Taiwanese patients with ankylosing spondylitis [J] . Ming-Han Chen, Wei-Sheng Chen, Hui-Ting Lee, Clinical Rheumatology . 2011,第9期

机译：台湾强直性脊柱炎患者中T细胞程序性死亡1（PD-1）表达与脊柱放射学变化呈负相关
4. Overexpression and Unique Rearrangement of VH2Transcripts in Immunoglobulin Variable Heavy ChainGenes in Ankylosing Spondylitis Patients [C] . Yeon Joo Kim, Nayoung Kim, Min-Kyung Lee, EU-Korea Conference on Science and Technology . 2011

机译：在强调脊柱胸腺炎患者中免疫球蛋白可变重的vh2transcript的过度表达和独特重新排列
5. The implications of molecular diagnostics in clinicopathologic correlations in two disease processes: PSA serum levels in acute illnesses, and, prevalence of activated protein C resistance and factor V mutation in patients with thrombosis and in control patients by ethnic group. [D] . Honda, Stacey Ann Akemi. 2002

机译：分子诊断在两种疾病过程中的临床病理相关性中的意义：急性疾病中PSA血清水平，以及血栓形成患者和对照患者（按种族）的活化蛋白C抗性和因子V突变的患病率。
6. Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial [O] . Agnes Hartl, Joachim Sieper, Uta Syrbe, 2017

机译：强直性脊柱炎患者的血清瘦素和高分子量脂联素水平与影像学脊髓发育呈负相关：ENRADAS试验结果
7. Inverse Correlation between CD4+CD25HighCD127low/− Regulatory T-Cells and Serum Immunoglobulin A in Patients with New-Onset Ankylosing Spondylitis [O] . S-S Zhao, J-W Hu, J Wang, 2011

机译：CD4 + CD25Highcd127LOW / - 调节T细胞与新发病脊柱炎患者血清免疫球蛋白A之间的反相相关性

Inverse Correlation between CD4+CD25HighCD127low/? Regulatory T-Cells and Serum Immunoglobulin A in Patients with New-Onset Ankylosing Spondylitis

摘要

著录项

相似文献

相关主题

期刊订阅