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首页> 外文期刊>Journal of International Medical Research >Efficacy and Safety of Morniflumate for the Treatment of Symptoms Associated with Soft Tissue Inflammation
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Efficacy and Safety of Morniflumate for the Treatment of Symptoms Associated with Soft Tissue Inflammation

机译：莫尼氟酯治疗软组织炎症相关症状的疗效和安全性

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摘要

The effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) for the management of pain in osteoarthritis and other musculoskeletal diseases is well documented. The role of NSAIDs is less clear in the treatment of conditions involving soft tissue inflammation, including the airways, ear–nose–throat (ENT) system and urogenital tract. These conditions are often treated inappropriately with antibiotics. Morniflumate, the ?-morpholinoethyl ester of niflumic acid, is a member of the fenamate family of NSAIDs indicated for the treatment of inflammatory conditions (with or without pain) affecting airways, the ENT system, urogenital tract and the osteoarticular system. Morniflumate has a 30-year history of clinical use, particularly for the treatment of pain associated with paediatric ENT infection. This article reviews evidence supporting the efficacy and safety of morniflumate. Based on available evidence and the favourable tolerability profile emerging from extensive clinical use, morniflumate appears to be a valid and well-tolerated alternative to other NSAIDs, or to antibiotics, for the treatment of pain and other symptoms of soft tissue inflammation.
机译：非甾体类抗炎药（NSAIDs）在治疗骨关节炎和其他肌肉骨骼疾病中的疼痛方面的有效性已得到充分证明。 NSAID在涉及软组织炎症的疾病（包括气道，耳鼻喉（ENT）系统和泌尿生殖道）的治疗中作用尚不清楚。这些情况通常不适当地用抗生素治疗。 Morniflumate（尼氟酸的α-吗啉代乙酯）是NSAID的fenamate家族的成员，被指定用于治疗影响气道，ENT系统，泌尿生殖道和骨关节系统的炎性疾病（有或无疼痛）。 Morniflumate具有30年的临床使用历史，尤其是用于治疗与小儿ENT感染相关的疼痛。本文回顾了支持莫尼氟酯疗效和安全性的证据。根据现有证据和广泛临床应用中产生的良好耐受性，莫尼氟酯似乎是其他NSAID或抗生素的有效且耐受性良好的替代品，可用于治疗疼痛和软组织炎症的其他症状。

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