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首页> 外文期刊>Journal of International Medical Research >Effects of palonosetron and ondansetron on preventing nausea and vomiting after laparoscopic surgery
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Effects of palonosetron and ondansetron on preventing nausea and vomiting after laparoscopic surgery

机译：帕洛诺司琼和恩丹西酮对预防腹腔镜手术后恶心和呕吐的作用

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Background This meta-analysis was performed to evaluate the efficacy and safety of palonosetron and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic surgery with general anesthesia. Methods We searched for randomized controlled clinical trials in PubMed, Embase, and The Cochrane Library. Results Nine studies were enrolled in this meta-analysis and showed no statistically significant difference between palonosetron and ondansetron in the prevention of PONV in the first 24 hours after surgery (relative risk [RR], 0.62; 95% confidence interval [CI], 0.35–1.10). Palonosetron more effectively prevented vomiting at various time intervals during the first 24 hours postoperatively than did ondansetron: 0–2 hours (RR, 0.45; 95% CI, 0.26–0.78), 2–6 hours (RR, 0.74; 95% CI, 0.39–1.40), and 6–24 hours (RR, 1.20; 95% CI, 0.55–2.64). No significant differences in side effects were found between palonosetron and ondansetron (RR, 0.67; 95% CI, 0.40–1.14). Conclusion This meta-analysis demonstrated that palonosetron is not more efficacious than ondansetron in the prevention of early PONV. However, palonosetron was more efficacious than ondansetron in the prevention of vomiting after laparoscopic surgery.
机译：背景本荟萃分析旨在评估帕洛诺司琼和恩丹西酮在接受全身麻醉的腹腔镜手术患者预防术后恶心和呕吐（PONV）方面​​的有效性和安全性。方法我们在PubMed，Embase和The Cochrane Library中搜索了随机对照临床试验。结果该荟萃分析共纳入9项研究，显示帕洛诺司琼和恩丹西酮在术后24小时内预防PONV方面无统计学差异（相对风险[RR]为0.62; 95％置信区间[CI]为0.35） –1.10）。帕洛诺司琼比恩丹西酮更有效地预防了术后头24小时在各个时间间隔的呕吐：0–2小时（RR，0.45; 95％CI，0.26-0.78），2–6小时（RR，0.74; 95％CI， 0.39–1.40）和6–24小时（RR，1.20; 95％CI，0.55-2.64）。帕洛诺司琼和昂丹司琼之间的副作用无显着差异（RR，0.67; 95％CI，0.40-1.14）。结论这项荟萃分析表明，帕洛诺司琼在预防早期PONV方面不比昂丹司琼有效。但是，帕洛诺司琼在预防腹腔镜手术后呕吐方面比恩丹西酮更有效。

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