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首页> 外文期刊>Journal of International Medical Research >Association between monocyte chemoattractant protein-1 and blood pressure in smokers
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Association between monocyte chemoattractant protein-1 and blood pressure in smokers

机译：吸烟者单核细胞趋化蛋白-1与血压的关系

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Objective The expression level of monocyte chemoattractant protein-1 (MCP-1) is increased in atherosclerotic regions, inducing monocyte migration to the blood vessel wall. Although the serum MCP-1 concentration is higher in patients with than without cardiovascular disease, the precise correlations between the serum MCP-1 concentration and factors associated with smoking and atherosclerosis are unknown. Methods The serum MCP-1 concentration was measured using an enzyme-linked immunosorbent assay in 207 consecutive smokers who visited our smoking cessation clinic. Results Sex-adjusted analysis of smokers revealed that the MCP-1 concentration was positively correlated with age ( β ?=?0.311), smoking duration ( β ?=?0.342), systolic blood pressure ( β ?=?0.225), and diastolic blood pressure ( β ?=?0.137) but not with the body mass index. Multivariate regression analysis showed that smoking duration and systolic blood pressure were independent determinants of the MCP-1 concentration. Conclusions The MCP-1 concentration was positively correlated with blood pressure among smokers. Long-term smokers with high blood pressure may be more susceptible to plaque rupture at atherosclerotic lesion sites.
机译：目的提高动脉粥样硬化区域单核细胞趋化蛋白-1（MCP-1）的表达水平，诱导单核细胞向血管壁的迁移。尽管有心血管疾病的患者的血清MCP-1浓度较高，但是尚不清楚血清MCP-1浓度与吸烟和动脉粥样硬化相关因素之间的确切相关性。方法采用酶联免疫吸附法测定207例连续戒烟的吸烟者的血清MCP-1水平。结果对吸烟者进行性别校正后的分析表明，MCP-1浓度与年龄（β= 0.311），吸烟时间（β= 0.342），收缩压（β= 0.225）和舒张压呈正相关。血压（β？=？0.137），但与体重指数无关。多元回归分析表明，吸烟时间和收缩压是MCP-1浓度的独立决定因素。结论吸烟者中MCP-1浓度与血压呈正相关。长期吸烟的高血压患者更容易在动脉粥样硬化病变部位发生斑块破裂。

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