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首页> 外文期刊>Journal of International Medical Research >Effects of periodontal therapy on eradication and recurrence of Helicobacter pylori infection after successful treatment
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Effects of periodontal therapy on eradication and recurrence of Helicobacter pylori infection after successful treatment

机译：牙周治疗对成功治疗后幽门螺杆菌感染的根除和复发的影响

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Objectives This study aimed to evaluate the effects of periodontal therapy on the efficacy of Helicobacter pylori eradication and on the recurrence of infection after eradication. Methods We conducted a prospective randomized trial on 698 gastric H. pylori -infected patients, of whom 347 received gastric H. pylori treatment alone and 342 received gastric H. pylori treatment plus periodontal therapy. The presence of H. pylori and associated virulence genes were detected by real-time polymerase chain reaction. Results After eradication of gastric H. pylori infection, the recurrence of gastric H. pylori was significantly lower in the gastric H. pylori treatment plus periodontal therapy group than in the group receiving gastric H. pylori treatment alone (OR 0.67; 95% CI 0.45 to 0.99), whereas the eradication rate was not significantly different (OR 0.87; 95% CI 0.68 to 0.98). There was a close relationship between the presence of H. pylori in saliva and its presence in the stomach. Conclusions The oral cavity is an important reservoir for gastric H. pylori infection. Adjunctive periodontal therapy could enhance the efficiency of H. pylori treatment and reduce the recurrence of gastric H. pylori infection.
机译：目的本研究旨在评估牙周治疗对根除幽门螺杆菌的效果以及根除后感染复发的影响。方法我们对698例胃幽门螺杆菌感染患者进行了一项前瞻性随机试验，其中347例接受单独的胃幽门螺杆菌治疗，342例接受胃幽门螺杆菌治疗加牙周治疗。通过实时聚合酶链反应检测幽门螺杆菌和相关毒力基因的存在。结果根除胃幽门螺杆菌感染后，胃幽门螺杆菌治疗加牙周治疗组的胃幽门螺杆菌复发率明显低于单独接受胃幽门螺杆菌治疗的患者（OR 0.67; 95％CI 0.45到0.99），而根除率没有显着差异（OR为0.87; 95％CI为0.68至0.98）。唾液中幽门螺杆菌的存在与其在胃中的存在密切相关。结论口腔是胃幽门螺杆菌感染的重要来源。牙周辅助治疗可以提高幽门螺杆菌的治疗效率，减少胃幽门螺杆菌感染的复发。

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