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首页> 外文期刊>Journal of King Saud University >Effect of Bakumondo-to on cytochrome P450 activities in rat liver microsomes
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Effect of Bakumondo-to on cytochrome P450 activities in rat liver microsomes

机译：Bakumondo-to对大鼠肝微粒体细胞色素P450活性的影响

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摘要

Bakumondo-to is a traditional herbal medicine. It has been widely used for the treatment of chronic airway diseases. Recently, it was reported that several herbal medicines affected cytochrome P450 (CYP). However, there is little information about the effects of Bakumondo-to on CYP activities. In this study, we evaluated the effects of Bakumondo-to on CYP activities in rat liver microsomes. Rats were orally treated twice a day with Bakumondo-to at doses of 2.0 g/kg body weight/day for 4 days. CYP activities were determined in liver microsomes isolated from treated rats. CYP1A2, CYP2C, and CYP3A activities were measured using their specific substrates [7-methoxyresorufin, 7-methoxy-4-(trifluoromethyl)-coumarin, and 7-benzyloxyquinoline, respectively]. Bakumondo-to decreased CYP1A2 activity by 42.5 ± 7.8%, increased CYP2C activity by 158.0 ± 29.6%, and decreased CYP3A activity to 81.5 ± 7.8% of the control level. Activities were expressed as percentages of the control. Bakumondo-to induced CYP2C activity and decreased CYP1A2 activity; it may cause drug-herbal interactions. It is suggested that combinations of Bakumondo-to and drugs that are metabolized by CYP1A2 and CYP2C should be carefully used in clinical settings.
机译：Bakumondo-to是一种传统草药。它已被广泛用于治疗慢性气道疾病。最近，有报道说几种草药会影响细胞色素P450（CYP）。但是，关于Bakumondo-to对CYP活性的影响的信息很少。在这项研究中，我们评估了Bakumondo-to对大鼠肝微粒体CYP活性的影响。每天用Bakumondo-to口服两次大鼠，剂量为2.0 g / kg体重/天，持续4天。在从治疗大鼠中分离的肝微粒体中测定CYP活性。 CYP1A2，CYP2C和CYP3A活性是使用它们的特定底物[分别是7-甲氧基间苯二酚，7-甲氧基-4-（三氟甲基）-香豆素和7-苄氧基喹啉]测量的。 Bakumondo-to使CYP1A2活性降低42.5±7.8％，使CYP2C活性升高158.0±29.6％，并使CYP3A活性降低至对照组水平的81.5±7.8％。活动表示为对照的百分比。 Bakumondo-to诱导CYP2C活性而降低CYP1A2活性;它可能导致药草相互作用。建议在临床环境中谨慎使用Bakumondo-to和被CYP1A2和CYP2C代谢的药物的组合。

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