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首页> 外文期刊>Journal of King Saud University >Antioxidant and antineoplastic activities of methanolic extract of Kaempferia galanga Linn. Rhizome against Ehrlich ascites carcinoma cells
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Antioxidant and antineoplastic activities of methanolic extract of Kaempferia galanga Linn. Rhizome against Ehrlich ascites carcinoma cells

机译：Kaempferia galanga Linn甲醇提取物的抗氧化和抗肿瘤活性。根茎抗艾氏腹水癌细胞

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As sources of natural products, medicinal plants bear a great interest for researcher in recent decades and this interest has increased considerably in finding naturally occurring antioxidant and antineoplastic compounds.Kaempferia galangalLinn., is an important member of medicinal flora available in Bangladesh and used traditionally for the prevention of numerous diseases. The present study was designed to investigate the antioxidant and antineoplastic activities of methanol extract ofKaempferia galangarhizome (MEKGR).In vitromodels and MTT assays were used to determine the antioxidant andin vitroantineoplastic properties of MEKGR. Antineoplastic effect of MEKGR against Ehrlich ascites carcinoma (EAC) were assessedin vivoby evaluating the viable tumor cell count, survival time, body weight gain due to tumor burden, observing morphological changes and nuclear damage of EAC cells by fluorescence microscope and estimating hematological profiles of experimental mice. Chemical composition was also analyzed by GC–MS. Treatment with MEKGR significantly (p<0.05) reduced viable EAC cells and weight gain and increased life span. MEKGR restored all hematological parameters, such as RBC, WBC, hemoglobin (Hb%) of EAC-bearing mice towards normal level. Membrane blebbing, chromatin condensation, nuclear fragmentations were observed after treatment with MEKGR. MEKGR exhibited strong antioxidant activity. TPC (Total phenolic content) and TFC (Total flavonoid content) were found strongly correlated (P<0.05) with antioxidant activities of MEKGR. 2-Propenoic acid, phthalic acid, palmitic acid, sandaracopimaradiene, oleic acid, octadecanoic acid, 2-[2-(4-nonylphenoxy) ethoxy] ethanol and glycidyl stearate were identified as the major constituents of MEKGR by GC–MS analysis. The overall findings of this study suggest that MEKGR may provide a natural source of antioxidant and antineoplastic activities.
机译：作为天然产物的来源，近几十年来，药用植物引起了研究人员的极大兴趣，并且在寻找天然存在的抗氧化剂和抗肿瘤化合物方面，这种兴趣已经大大提高。KaempferiagalangalLinn。是孟加拉国药用植物的重要成员，传统上用于预防多种疾病。本研究旨在研究甘蓝Kaempferia galangarhizome（MEKGR）甲醇提取物的抗氧化和抗肿瘤活性。采用体外模型和MTT分析确定MEKGR的抗氧化和体外抗肿瘤性能。通过评估存活的肿瘤细胞数，存活时间，由于肿瘤负荷引起的体重增加，通过荧光显微镜观察EAC细胞的形态变化和核损伤并评估实验的血液学特征，评估了MEKGR对艾氏腹水癌（EAC）的抗肿瘤作用。老鼠。化学成分也通过GC-MS分析。用MEKGR治疗显着（p <0.05）减少了存活的EAC细胞，增加了体重，并延长了寿命。 MEKGR使所有带有EAC的小鼠的血液学参数（如RBC，WBC，血红蛋白（Hb％））恢复到正常水平。用MEKGR处理后观察到膜起泡，染色质浓缩，核碎裂。 MEKGR具有很强的抗氧化活性。 TPC（总酚含量）和TFC（总黄酮含量）与MEKGR的抗氧化活性密切相关（P <0.05）。通过GC-MS分析，确定了2-丙酸，邻苯二甲酸，棕榈酸，saraaracopimaradiene，油酸，十八烷酸，2- [2-（4-壬基苯氧基）乙氧基]乙醇和硬脂酸缩水甘油酯是MEKGR的主要成分。这项研究的总体结果表明，MEKGR可能提供抗氧化剂和抗肿瘤活性的天然来源。

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