...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of King Saud University >In-vitro phytopharmacological and anticancer activity of Loranthus Longiflorus Desv. Var. Falcatuskurz against the human lung cancer cells
【24h】

In-vitro phytopharmacological and anticancer activity of Loranthus Longiflorus Desv. Var. Falcatuskurz against the human lung cancer cells

机译：斜纹西番莲（Loranthus Longiflorus Desv）的体外植物药理和抗癌活性。 Var。 Falcatuskurz抗人肺癌细胞

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, we evaluated anticancer activity of methanol extract and purified compound fromLoranthus Longiflorusagainst Human lung cancer cells (A-549), human cervical carcinoma (HeLa) and human hepatocellular carcinoma cell line (HepG2). Cytotoxicity ofLoranthus Longifloruswas investigated using MTT assay. Doxorubicin was used as the positive control. MTT assay showed activity against all three tested cell lines. The cytotoxicity activities expressed as percentage of cell viability and the compound was effective on HepG2, HeLa and A-549 cell lines. Cytotoxicity of methanolic extract of LLF against A-549 cell line was measured and the IC50 value of methanol extract of LLF was 17?±?1.5?μg/ml. In HeLa cell line, the IC50 value of methanol extract of LLF was16?±?1.0?μg/ml. Cytotoxicity of methanolic extract of LLF against HepG2 cell line was also evaluated. IC50 value of Doxorubicin (standard) was 11?±?1.0?μg/ml and IC50 value of methanol extract of LLF was 18?±?0.5?μg/ml. Similarly cytotoxicity showed a significant activity of the compound LLF on HepG2, HeLa and A-549 cell lines. The IC50 values of compound were 13.5?±?1.5?μg/ml, 15?±?1.5?μg/ml, 17?±?0.5?μg/ml against A-549, HeLa and HepG2 cell lines. The present findings confirmed cytotoxic effect of methanol extract and purified compound fromLoranthus Longiflorusagainst A-549, HeLa and HepG2 cell lines.
机译：在这项研究中，我们评估了甲醇提取物和来自Loranthus Longiflorus的纯化化合物对人肺癌细胞（A-549），人宫颈癌（HeLa）和人肝细胞癌细胞系（HepG2）的抗癌活性。采用MTT法研究了长叶鸢尾的细胞毒性。阿霉素用作阳性对照。 MTT测定显示出针对所有三种测试的细胞系的活性。细胞毒性活性以细胞活力的百分比表示，该化合物对HepG2，HeLa和A-549细胞系有效。测定了LF的甲醇提取物对A-549细胞的细胞毒性，并且LF的甲醇提取物的IC 50值为17±1.5±1.5μg/ ml。在HeLa细胞系中，LLF甲醇提取物的IC50值为16？±？1.0？μg/ ml。还评估了LLF甲醇提取物对HepG2细胞系的细胞毒性。阿霉素（标准品）的IC50值为11±1.0±μg/ ml，LLF的甲醇提取物的IC50值为18±0.5μg/ ml。同样，细胞毒性显示化合物LLF对HepG2，HeLa和A-549细胞系具有显着活性。化合物对A-549，HeLa和HepG2细胞系的IC50值为13.5±1.5±μg/ ml，15±1.5μg/ ml，17±0.5μg/ ml。本发现证实了来自Loranthus Longiflorus的甲醇提取物和纯化的化合物对A-549，HeLa和HepG2细胞系的细胞毒性作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号