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首页> 外文期刊>Journal of King Saud University >Testing the cytotoxicity and genotoxicity of the antimalarial drug mefloquine
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Testing the cytotoxicity and genotoxicity of the antimalarial drug mefloquine

机译：测试抗疟药甲氟喹的细胞毒性和遗传毒性

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Numerous drugs show significant behavioral, developmental, teratogenic and mutagenic effects. This study investigates the cytotoxic and genotoxic effects of two doses (20 and 40 mg/kg body weight) of the antimalarial drug mefloquine (MQ), in male mice. The parameters included the assessment of: mitotic index, cell cycle kinetics, and frequency of chromosomal aberrations in bone marrow cells, translocation frequency in spermatocytes and head and tail abnormalities in sperm. A high dose of mefloquine resulted in a decreased mitotic index, suggesting a dose–response correlation. A notable recovery in mitotic activity was observed during the first and third week post treatment, which approached the mitotic index of control. Chromosomal abnormalities including gaps, breaks, and fragments also increased with the higher dose of mefloquine. Spermatids and secondary spermatocytes were moderately sensitive to the drug; whereas primary spermatocytes were more sensitive, and spermatogonia were highly sensitive to both doses of MQ. Conclusion Mefloquine (MQ) at the doses used can be considered as a drug with a potential mutagenic effect. The results obtained from the spermatocyte diakinesis-metaphase 1 test and sperm abnormalities suggest that MQ may contribute to high incidence of birth defects and congenital abnormalities.
机译：许多药物显示出显着的行为，发育，致畸和诱变作用。这项研究调查了两种剂量（20和40 mg / kg体重）抗疟药甲氟喹（MQ）对雄性小鼠的细胞毒性和遗传毒性作用。这些参数包括对以下各项的评估：有丝分裂指数，细胞周期动力学和骨髓细胞中染色体畸变的频率，精细胞的易位频率以及精子的头尾异常。高剂量甲氟喹导致有丝分裂指数降低，表明剂量反应关系。在治疗后的第一周和第三周，观察到有丝分裂活性的显着恢复，接近对照的有丝分裂指数。随着甲氟喹剂量的增加，包括缺口，断裂和碎片在内的染色体异常也会增加。精子细胞和继发性精母细胞对该药物中等敏感;而原代精母细胞更敏感，精原细胞对两种剂量的MQ高度敏感。结论甲氟喹（MQ）的剂量可以被认为是具有潜在诱变作用的药物。从精子细胞运动异常中期1测试和精子异常获得的结果表明，MQ可能导致出生缺陷和先天性异常的高发。

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