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首页> 外文期刊>Journal of International Medical Research >Vascular endothelial growth factor C expression is closely correlated with lymph node recurrence and poor prognosis in patients with early stage cervical cancer
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Vascular endothelial growth factor C expression is closely correlated with lymph node recurrence and poor prognosis in patients with early stage cervical cancer

机译：早期宫颈癌患者血管内皮生长因子C的表达与淋巴结复发及不良预后密切相关

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Objectives To detect vascular endothelial growth factor (VEGF)-C mRNA expression in surgically resected tissues of ‘pathologic N0’ (pN0) cervical cancer; to investigate the relevance of VEGF-C mRNA expression to clinicopathological factors, lymph node recurrence and prognosis in early stage cervical cancer. Methods Patients with pN0 cervical cancer who successfully underwent radical hysterectomy with bilateral adnexectomy and bilateral pelvic lymphadenectomy were enrolled sequentially into this retrospective study. Reverse transcriptase–polymerase chain reaction (RT–PCR) was performed to detect VEGF-C mRNA. Results Seventy-eight patients entered the study. VEGF-C mRNA was detected in 35 (44.87%) patients and was significantly correlated with tumour differentiation. VEGF-C mRNA expression was significantly associated with lymph node recurrence and poor overall survival 5 years after surgery. Multivariate analysis confirmed that VEGF-C mRNA expression was an independent predictor for lymph node recurrence and unfavourable overall survival. Conclusions These findings indicate that detection of VEGF-C mRNA has clinical potential as a predictor for identifying patients with pN0 cervical cancer at high risk of lymph node recurrence and poor prognosis.
机译：目的检测“病理N0”（pN0）宫颈癌手术切除组织中的血管内皮生长因子（VEGF）-C mRNA表达;目的探讨VEGF-C mRNA表达与早期宫颈癌临床病理因素，淋巴结复发及预后的关系。方法将pN0型宫颈癌成功进行了根治性子宫切除术，双侧附件切除术和双侧盆腔淋巴结切除术的患者纳入本回顾性研究。进行逆转录聚合酶链反应（RT-PCR）以检测VEGF-C mRNA。结果78例患者进入研究。在35例（44.87％）患者中检测到VEGF-C mRNA，并且与肿瘤分化显着相关。术后5年，VEGF-C mRNA的表达与淋巴结的复发和较差的总生存率显着相关。多变量分析证实，VEGF-C mRNA表达是淋巴结复发和总体生存不良的独立预测因子。结论这些发现表明，VEGF-C mRNA的检测具有临床潜力，可作为识别具有高淋巴结复发风险和不良预后的pN0宫颈癌患者的指标。

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